Neuroradiological features of traumatic encephalopathy syndrome using MRI and FDG-PET imaging: a case series in Australia
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| Main Authors: | , , , , , , |
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| Format: | Preprint |
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2024
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| _version_ | 1866912108321439744 |
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| author | Mobbs, Rowena Nasrallah, Fatima To, Xuan Vinh Magnussen, John Batchelor, Jennifer Hsiao, Edward Walterfang, Mark |
| author_facet | Mobbs, Rowena Nasrallah, Fatima To, Xuan Vinh Magnussen, John Batchelor, Jennifer Hsiao, Edward Walterfang, Mark |
| contents | Objectives: This study examined whether currently existing clinical structural magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (18FDG-PET) capabilities and board-certified radiologists' reports and interpretations can assist with traumatic encephalopathy syndrome (TES) diagnosis. Design: retrospective case series. Setting: this study assessed six patients with TES criteria recruited from the Sydney area, Australia Main outcomes: patients' clinical history and clinical presentation along TES diagnostic criteria, board-certified radiologist reports of structural MRI and 18FDG-PET. Results: one patient was classified as possible CTE, and the others were classified as probable CTE with significant RHI exposure history and a spectrum of cognitive deficits and other neuropsychiatric disturbances consistent with TES diagnostic criteria. Most common radiological features included atrophy of posterior superior parietal region and Evans Index > 0.25. FDG-PET's pattern of common regions of hypometabolism and differing hypometabolism across participants suggested that FDG-PET and structural MRI have the potential for stratifying different TES stages. Conclusions: this study highlights the potential of a combined clinical and radiological approach using solely current capabilities to improve TES diagnosis and suggests a larger study. Such expanded investigation is crucial for advancing the ante-mortem diagnosis and management of CTE. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2411_04334 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Neuroradiological features of traumatic encephalopathy syndrome using MRI and FDG-PET imaging: a case series in Australia Mobbs, Rowena Nasrallah, Fatima To, Xuan Vinh Magnussen, John Batchelor, Jennifer Hsiao, Edward Walterfang, Mark Neurons and Cognition Objectives: This study examined whether currently existing clinical structural magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (18FDG-PET) capabilities and board-certified radiologists' reports and interpretations can assist with traumatic encephalopathy syndrome (TES) diagnosis. Design: retrospective case series. Setting: this study assessed six patients with TES criteria recruited from the Sydney area, Australia Main outcomes: patients' clinical history and clinical presentation along TES diagnostic criteria, board-certified radiologist reports of structural MRI and 18FDG-PET. Results: one patient was classified as possible CTE, and the others were classified as probable CTE with significant RHI exposure history and a spectrum of cognitive deficits and other neuropsychiatric disturbances consistent with TES diagnostic criteria. Most common radiological features included atrophy of posterior superior parietal region and Evans Index > 0.25. FDG-PET's pattern of common regions of hypometabolism and differing hypometabolism across participants suggested that FDG-PET and structural MRI have the potential for stratifying different TES stages. Conclusions: this study highlights the potential of a combined clinical and radiological approach using solely current capabilities to improve TES diagnosis and suggests a larger study. Such expanded investigation is crucial for advancing the ante-mortem diagnosis and management of CTE. |
| title | Neuroradiological features of traumatic encephalopathy syndrome using MRI and FDG-PET imaging: a case series in Australia |
| topic | Neurons and Cognition |
| url | https://arxiv.org/abs/2411.04334 |