Causal Representation Learning from Multimodal Biomedical Observations
Fuente:
arXiv
Salvato in:
| Autori principali: | , , , , , , , , , , , , |
|---|---|
| Natura: | Preprint |
| Pubblicazione: |
2024
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1866915199407095808 |
|---|---|
| author | Sun, Yuewen Kong, Lingjing Chen, Guangyi Li, Loka Luo, Gongxu Li, Zijian Zhang, Yixuan Zheng, Yujia Yang, Mengyue Stojanov, Petar Segal, Eran Xing, Eric P. Zhang, Kun |
| author_facet | Sun, Yuewen Kong, Lingjing Chen, Guangyi Li, Loka Luo, Gongxu Li, Zijian Zhang, Yixuan Zheng, Yujia Yang, Mengyue Stojanov, Petar Segal, Eran Xing, Eric P. Zhang, Kun |
| contents | Prevalent in biomedical applications (e.g., human phenotype research), multimodal datasets can provide valuable insights into the underlying physiological mechanisms. However, current machine learning (ML) models designed to analyze these datasets often lack interpretability and identifiability guarantees, which are essential for biomedical research. Recent advances in causal representation learning have shown promise in identifying interpretable latent causal variables with formal theoretical guarantees. Unfortunately, most current work on multimodal distributions either relies on restrictive parametric assumptions or yields only coarse identification results, limiting their applicability to biomedical research that favors a detailed understanding of the mechanisms.
In this work, we aim to develop flexible identification conditions for multimodal data and principled methods to facilitate the understanding of biomedical datasets. Theoretically, we consider a nonparametric latent distribution (c.f., parametric assumptions in previous work) that allows for causal relationships across potentially different modalities. We establish identifiability guarantees for each latent component, extending the subspace identification results from previous work. Our key theoretical contribution is the structural sparsity of causal connections between modalities, which, as we will discuss, is natural for a large collection of biomedical systems. Empirically, we present a practical framework to instantiate our theoretical insights. We demonstrate the effectiveness of our approach through extensive experiments on both numerical and synthetic datasets. Results on a real-world human phenotype dataset are consistent with established biomedical research, validating our theoretical and methodological framework. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2411_06518 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Causal Representation Learning from Multimodal Biomedical Observations Sun, Yuewen Kong, Lingjing Chen, Guangyi Li, Loka Luo, Gongxu Li, Zijian Zhang, Yixuan Zheng, Yujia Yang, Mengyue Stojanov, Petar Segal, Eran Xing, Eric P. Zhang, Kun Machine Learning Quantitative Methods Methodology Prevalent in biomedical applications (e.g., human phenotype research), multimodal datasets can provide valuable insights into the underlying physiological mechanisms. However, current machine learning (ML) models designed to analyze these datasets often lack interpretability and identifiability guarantees, which are essential for biomedical research. Recent advances in causal representation learning have shown promise in identifying interpretable latent causal variables with formal theoretical guarantees. Unfortunately, most current work on multimodal distributions either relies on restrictive parametric assumptions or yields only coarse identification results, limiting their applicability to biomedical research that favors a detailed understanding of the mechanisms. In this work, we aim to develop flexible identification conditions for multimodal data and principled methods to facilitate the understanding of biomedical datasets. Theoretically, we consider a nonparametric latent distribution (c.f., parametric assumptions in previous work) that allows for causal relationships across potentially different modalities. We establish identifiability guarantees for each latent component, extending the subspace identification results from previous work. Our key theoretical contribution is the structural sparsity of causal connections between modalities, which, as we will discuss, is natural for a large collection of biomedical systems. Empirically, we present a practical framework to instantiate our theoretical insights. We demonstrate the effectiveness of our approach through extensive experiments on both numerical and synthetic datasets. Results on a real-world human phenotype dataset are consistent with established biomedical research, validating our theoretical and methodological framework. |
| title | Causal Representation Learning from Multimodal Biomedical Observations |
| topic | Machine Learning Quantitative Methods Methodology |
| url | https://arxiv.org/abs/2411.06518 |