Control-Oriented Models Inform Synthetic Biology Strategies in CAR T Cell Immunotherapy
Fuente:
arXiv
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| Autore principale: | |
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| Natura: | Preprint |
| Pubblicazione: |
2024
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| _version_ | 1866929589038612480 |
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| author | Romagnoli, Raffaele |
| author_facet | Romagnoli, Raffaele |
| contents | Chimeric antigen receptor (CAR) T cell therapy is revolutionizing the treatment of blood cancers. Mathematical models that can predict the effectiveness of immunotherapies such as CAR T are of increasing interest due to their ability to reduce the number of experiments performed and to guide the theoretical development of new therapeutic strategies. {Following this rationale, we propose the use of control-oriented models to guide the augmentation of CAR T therapy with synthetic gene circuitry. Here we present an initial investigation where we adapt a previously developed CAR T model for control-oriented purposes. We then explore the impact of realistic alternative activation methods as control inputs to ensure effective tumor clearance. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2411_07927 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Control-Oriented Models Inform Synthetic Biology Strategies in CAR T Cell Immunotherapy Romagnoli, Raffaele Systems and Control Chimeric antigen receptor (CAR) T cell therapy is revolutionizing the treatment of blood cancers. Mathematical models that can predict the effectiveness of immunotherapies such as CAR T are of increasing interest due to their ability to reduce the number of experiments performed and to guide the theoretical development of new therapeutic strategies. {Following this rationale, we propose the use of control-oriented models to guide the augmentation of CAR T therapy with synthetic gene circuitry. Here we present an initial investigation where we adapt a previously developed CAR T model for control-oriented purposes. We then explore the impact of realistic alternative activation methods as control inputs to ensure effective tumor clearance. |
| title | Control-Oriented Models Inform Synthetic Biology Strategies in CAR T Cell Immunotherapy |
| topic | Systems and Control |
| url | https://arxiv.org/abs/2411.07927 |