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| Main Authors: | , , , , , , , |
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| Format: | Preprint |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2411.08237 |
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| _version_ | 1866915292932734976 |
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| author | Zou, Sarah J Lim, Irene Foster, Jackson W Chinn, Garry Houson, Hailey A Lapi, Suzanne E. Rao, Jianghong Levin, Craig S |
| author_facet | Zou, Sarah J Lim, Irene Foster, Jackson W Chinn, Garry Houson, Hailey A Lapi, Suzanne E. Rao, Jianghong Levin, Craig S |
| contents | In this study, we explore the use of Co-55 as a radioisotope for multiplexed PET (mPET) by utilizing its emission of a prompt gamma-ray in cascade with a positron during decay. We leverage the prompt-gamma signal to generate triple coincidences for a Co-55-labeled tracer, allowing us to distinguish it from a tracer labeled with a pure positron emitter, such as F-18. By employing triple versus double coincidence detection and signal processing methodology, we successfully separate the Co-55 signal from that of F-18. Phantom studies were conducted to establish the correlation between Co-55 double and triple coincidence counts and Co-55 activity. Additionally, we demonstrate the potential for quantifying hot spots within a warm background produced by both Co-55 and F-18 signals in a single PET scan. Finally, we showcase the ability to simultaneously image two tracers in vivo in a single PET session with mouse models of cancer. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2411_08237 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Quantitative Imaging of $^{55}\text{Co}$ and $^{18}\text{F}$-Labeled Tracers in a Single "Multiplexed" PET Imaging Session Zou, Sarah J Lim, Irene Foster, Jackson W Chinn, Garry Houson, Hailey A Lapi, Suzanne E. Rao, Jianghong Levin, Craig S Medical Physics In this study, we explore the use of Co-55 as a radioisotope for multiplexed PET (mPET) by utilizing its emission of a prompt gamma-ray in cascade with a positron during decay. We leverage the prompt-gamma signal to generate triple coincidences for a Co-55-labeled tracer, allowing us to distinguish it from a tracer labeled with a pure positron emitter, such as F-18. By employing triple versus double coincidence detection and signal processing methodology, we successfully separate the Co-55 signal from that of F-18. Phantom studies were conducted to establish the correlation between Co-55 double and triple coincidence counts and Co-55 activity. Additionally, we demonstrate the potential for quantifying hot spots within a warm background produced by both Co-55 and F-18 signals in a single PET scan. Finally, we showcase the ability to simultaneously image two tracers in vivo in a single PET session with mouse models of cancer. |
| title | Quantitative Imaging of $^{55}\text{Co}$ and $^{18}\text{F}$-Labeled Tracers in a Single "Multiplexed" PET Imaging Session |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2411.08237 |