Comprehensive and Practical Evaluation of Retrieval-Augmented Generation Systems for Medical Question Answering

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Main Authors: Ngo, Nghia Trung, Van Nguyen, Chien, Dernoncourt, Franck, Nguyen, Thien Huu
Format: Preprint
Published: 2024
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author Ngo, Nghia Trung
Van Nguyen, Chien
Dernoncourt, Franck
Nguyen, Thien Huu
author_facet Ngo, Nghia Trung
Van Nguyen, Chien
Dernoncourt, Franck
Nguyen, Thien Huu
contents Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical domain necessitates a completely accurate and trustworthy system. While existing RAG benchmarks primarily focus on the standard retrieve-answer setting, they overlook many practical scenarios that measure crucial aspects of a reliable medical system. This paper addresses this gap by providing a comprehensive evaluation framework for medical question-answering (QA) systems in a RAG setting for these situations, including sufficiency, integration, and robustness. We introduce Medical Retrieval-Augmented Generation Benchmark (MedRGB) that provides various supplementary elements to four medical QA datasets for testing LLMs' ability to handle these specific scenarios. Utilizing MedRGB, we conduct extensive evaluations of both state-of-the-art commercial LLMs and open-source models across multiple retrieval conditions. Our experimental results reveals current models' limited ability to handle noise and misinformation in the retrieved documents. We further analyze the LLMs' reasoning processes to provides valuable insights and future directions for developing RAG systems in this critical medical domain.
format Preprint
id arxiv_https___arxiv_org_abs_2411_09213
institution arXiv
publishDate 2024
record_format arxiv
spellingShingle Comprehensive and Practical Evaluation of Retrieval-Augmented Generation Systems for Medical Question Answering
Ngo, Nghia Trung
Van Nguyen, Chien
Dernoncourt, Franck
Nguyen, Thien Huu
Computation and Language
Artificial Intelligence
Information Retrieval
Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical domain necessitates a completely accurate and trustworthy system. While existing RAG benchmarks primarily focus on the standard retrieve-answer setting, they overlook many practical scenarios that measure crucial aspects of a reliable medical system. This paper addresses this gap by providing a comprehensive evaluation framework for medical question-answering (QA) systems in a RAG setting for these situations, including sufficiency, integration, and robustness. We introduce Medical Retrieval-Augmented Generation Benchmark (MedRGB) that provides various supplementary elements to four medical QA datasets for testing LLMs' ability to handle these specific scenarios. Utilizing MedRGB, we conduct extensive evaluations of both state-of-the-art commercial LLMs and open-source models across multiple retrieval conditions. Our experimental results reveals current models' limited ability to handle noise and misinformation in the retrieved documents. We further analyze the LLMs' reasoning processes to provides valuable insights and future directions for developing RAG systems in this critical medical domain.
title Comprehensive and Practical Evaluation of Retrieval-Augmented Generation Systems for Medical Question Answering
topic Computation and Language
Artificial Intelligence
Information Retrieval
url https://arxiv.org/abs/2411.09213