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| Main Authors: | , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2411.18110 |
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| _version_ | 1866909406198759424 |
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| author | Sun, Jiacheng Li, Fajun Wang, Xudong He, Jing Ni, Dangwu Wang, Lang Lin, Shaowei Min, Qiu Zhu, Jinfeng Wen, Liaoyong |
| author_facet | Sun, Jiacheng Li, Fajun Wang, Xudong He, Jing Ni, Dangwu Wang, Lang Lin, Shaowei Min, Qiu Zhu, Jinfeng Wen, Liaoyong |
| contents | Optical metasurface has brought a revolution in label-free molecular sensing, attracting extensive attention. Currently, such sensing approaches are being designed to respond to peak wavelengths with a higher Q factor in the visible and near-infrared regions.Nevertheless, a higher Q factor that enhances light confinement will inevitably deteriorate the wavelength sensitivity and complicate the sensing system. We propose a Q-switched sensing mechanism, which enables the real part of the refractive index to effectively perturbate the damping loss of the oscillator, resulting in a boost of peak intensity.Consequently, a higher Q factor in Q-switched sensor can further enhance the peak sensitivity while remaining compatible with broadband light sources, simultaneously meeting the requirements of high performance and a compact system.This is achieved in a unique 3D bound-state-in-continuum (BIC) metasurface which can be mass-produced by wafer-scale aluminum-nanoimprinting technology and provides a peak intensity sensitivity up to 928 %/RIU.Therefore, a miniaturized BIC biosensing system is realized, with a limit of detection to 10E-5 refractive index units and 129 aM extracellular vesicles in clinical lung cancer diagnosis, both of which are magnitudes lower than those of current state-of-the-art biosensors. It further demonstrates significant potential for home cancer self-testing equipment for post-operative follow-up. This Q-switched sensing mechanism offers a new perspective for the commercialization of advanced and practical BIC optical biosensing systems in real-setting scenarios. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2411_18110 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Loss-driven miniaturized bound state in continuum biosensing system Sun, Jiacheng Li, Fajun Wang, Xudong He, Jing Ni, Dangwu Wang, Lang Lin, Shaowei Min, Qiu Zhu, Jinfeng Wen, Liaoyong Optics Optical metasurface has brought a revolution in label-free molecular sensing, attracting extensive attention. Currently, such sensing approaches are being designed to respond to peak wavelengths with a higher Q factor in the visible and near-infrared regions.Nevertheless, a higher Q factor that enhances light confinement will inevitably deteriorate the wavelength sensitivity and complicate the sensing system. We propose a Q-switched sensing mechanism, which enables the real part of the refractive index to effectively perturbate the damping loss of the oscillator, resulting in a boost of peak intensity.Consequently, a higher Q factor in Q-switched sensor can further enhance the peak sensitivity while remaining compatible with broadband light sources, simultaneously meeting the requirements of high performance and a compact system.This is achieved in a unique 3D bound-state-in-continuum (BIC) metasurface which can be mass-produced by wafer-scale aluminum-nanoimprinting technology and provides a peak intensity sensitivity up to 928 %/RIU.Therefore, a miniaturized BIC biosensing system is realized, with a limit of detection to 10E-5 refractive index units and 129 aM extracellular vesicles in clinical lung cancer diagnosis, both of which are magnitudes lower than those of current state-of-the-art biosensors. It further demonstrates significant potential for home cancer self-testing equipment for post-operative follow-up. This Q-switched sensing mechanism offers a new perspective for the commercialization of advanced and practical BIC optical biosensing systems in real-setting scenarios. |
| title | Loss-driven miniaturized bound state in continuum biosensing system |
| topic | Optics |
| url | https://arxiv.org/abs/2411.18110 |