Traction force microscopy for linear and nonlinear elastic materials as a parameter identification inverse problem
Fuente:
arXiv
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2024
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866912138094706688 |
|---|---|
| author | Sarnighausen, Gesa Nguyen, Tram Thi Ngoc Hohage, Thorsten Sinha, Mangalika Koester, Sarah Betz, Timo Schwarz, Ulrich Sebastian Wald, Anne |
| author_facet | Sarnighausen, Gesa Nguyen, Tram Thi Ngoc Hohage, Thorsten Sinha, Mangalika Koester, Sarah Betz, Timo Schwarz, Ulrich Sebastian Wald, Anne |
| contents | Traction force microscopy is a method widely used in biophysics and cell biology to determine forces that biological cells apply to their environment. In the experiment, the cells adhere to a soft elastic substrate, which is then deformed in response to cellular traction forces. The inverse problem consists in computing the traction stress applied by the cell from microscopy measurements of the substrate deformations. In this work, we consider a linear model, in which 3D forces are applied at a 2D interface, called 2.5D traction force microscopy, and a nonlinear pure 2D model, from which we directly obtain a linear pure 2D model. All models lead to a linear resp. nonlinear parameter identification problem for a boundary value problem of elasticity. We analyze the respective forward operators and conclude with some numerical experiments for simulated and experimental data. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2411_19917 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Traction force microscopy for linear and nonlinear elastic materials as a parameter identification inverse problem Sarnighausen, Gesa Nguyen, Tram Thi Ngoc Hohage, Thorsten Sinha, Mangalika Koester, Sarah Betz, Timo Schwarz, Ulrich Sebastian Wald, Anne Numerical Analysis 92-08, 35Q92, 35R30 Traction force microscopy is a method widely used in biophysics and cell biology to determine forces that biological cells apply to their environment. In the experiment, the cells adhere to a soft elastic substrate, which is then deformed in response to cellular traction forces. The inverse problem consists in computing the traction stress applied by the cell from microscopy measurements of the substrate deformations. In this work, we consider a linear model, in which 3D forces are applied at a 2D interface, called 2.5D traction force microscopy, and a nonlinear pure 2D model, from which we directly obtain a linear pure 2D model. All models lead to a linear resp. nonlinear parameter identification problem for a boundary value problem of elasticity. We analyze the respective forward operators and conclude with some numerical experiments for simulated and experimental data. |
| title | Traction force microscopy for linear and nonlinear elastic materials as a parameter identification inverse problem |
| topic | Numerical Analysis 92-08, 35Q92, 35R30 |
| url | https://arxiv.org/abs/2411.19917 |