Dynamic optical coherence tomography algorithm for label-free assessment of swiftness and occupancy of intratissue moving scatterers
Fuente:
arXiv
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Preprint |
| Publicado: |
2024
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866918250991845376 |
|---|---|
| author | Morishita, Rion Mukherjee, Pradipta El-Sadek, Ibrahim Abd Seesan, Tanatchaya Mori, Tomoko Furukawa, Atsuko Fukuda, Shinichi Lukmanto, Donny Matsusaka, Satoshi Makita, Shuichi Yasuno, Yoshiaki |
| author_facet | Morishita, Rion Mukherjee, Pradipta El-Sadek, Ibrahim Abd Seesan, Tanatchaya Mori, Tomoko Furukawa, Atsuko Fukuda, Shinichi Lukmanto, Donny Matsusaka, Satoshi Makita, Shuichi Yasuno, Yoshiaki |
| contents | Dynamic optical coherence tomography (DOCT) statistically analyzes fluctuations in time-sequential OCT signals, enabling label-free and three-dimensional visualization of intratissue and intracellular activities. Current DOCT methods, such as logarithmic intensity variance (LIV) and OCT correlation decay speed (OCDS) have several limitations.Namely, the DOCT values and intratissue motions are not directly related, and hence DOCT values are not interpretable in the context of the tissue motility. We introduce a new DOCT algorithm that provides more direct interpretation of DOCT in the contexts of dynamic scatterer ratio and scatterer speed in the tissue.The detailed properties of the new and conventional DOCT methods are investigated by numerical simulations, and the experimental validation with in vitro and ex vivo samples demonstrates the feasibility of the new method. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2412_09351 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Dynamic optical coherence tomography algorithm for label-free assessment of swiftness and occupancy of intratissue moving scatterers Morishita, Rion Mukherjee, Pradipta El-Sadek, Ibrahim Abd Seesan, Tanatchaya Mori, Tomoko Furukawa, Atsuko Fukuda, Shinichi Lukmanto, Donny Matsusaka, Satoshi Makita, Shuichi Yasuno, Yoshiaki Optics Biological Physics Medical Physics Dynamic optical coherence tomography (DOCT) statistically analyzes fluctuations in time-sequential OCT signals, enabling label-free and three-dimensional visualization of intratissue and intracellular activities. Current DOCT methods, such as logarithmic intensity variance (LIV) and OCT correlation decay speed (OCDS) have several limitations.Namely, the DOCT values and intratissue motions are not directly related, and hence DOCT values are not interpretable in the context of the tissue motility. We introduce a new DOCT algorithm that provides more direct interpretation of DOCT in the contexts of dynamic scatterer ratio and scatterer speed in the tissue.The detailed properties of the new and conventional DOCT methods are investigated by numerical simulations, and the experimental validation with in vitro and ex vivo samples demonstrates the feasibility of the new method. |
| title | Dynamic optical coherence tomography algorithm for label-free assessment of swiftness and occupancy of intratissue moving scatterers |
| topic | Optics Biological Physics Medical Physics |
| url | https://arxiv.org/abs/2412.09351 |