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| Hauptverfasser: | , , , |
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| Format: | Preprint |
| Veröffentlicht: |
2024
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| Online-Zugang: | https://arxiv.org/abs/2412.10031 |
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| _version_ | 1866911172595286016 |
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| author | Liu, Jizhihui Teng, Qixun Ma, Qing Jiang, Junjun |
| author_facet | Liu, Jizhihui Teng, Qixun Ma, Qing Jiang, Junjun |
| contents | Fluorescence microscopy image (FMI) denoising faces critical challenges due to the compound mixed Poisson-Gaussian noise with strong spatial correlation and the impracticality of acquiring paired noisy/clean data in dynamic biomedical scenarios. While supervised methods trained on synthetic noise (e.g., Gaussian/Poisson) suffer from out-of-distribution generalization issues, existing self-supervised approaches degrade under real FMI noise due to oversimplified noise assumptions and computationally intensive deep architectures. In this paper, we propose Fluorescence Micrograph to Self (FM2S), a zero-shot denoiser that achieves efficient FMI denoising through three key innovations: 1) A noise injection module that ensures training data sufficiency through adaptive Poisson-Gaussian synthesis while preserving spatial correlation and global statistics of FMI noise for robust model generalization; 2) A two-stage progressive learning strategy that first recovers structural priors via pre-denoised targets then refines high-frequency details through noise distribution alignment; 3) An ultra-lightweight network (3.5k parameters) enabling rapid convergence with 270$\times$ faster training and inference than SOTAs. Extensive experiments across FMI datasets demonstrate FM2S's superiority: It outperforms CVF-SID by 1.4dB PSNR on average while requiring 0.1% parameters of AP-BSN. Notably, FM2S maintains stable performance across varying noise levels, proving its practicality for microscopy platforms with diverse sensor characteristics. Code and datasets will be released. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2412_10031 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | FM2S: Towards Spatially-Correlated Noise Modeling in Zero-Shot Fluorescence Microscopy Image Denoising Liu, Jizhihui Teng, Qixun Ma, Qing Jiang, Junjun Image and Video Processing Computer Vision and Pattern Recognition Fluorescence microscopy image (FMI) denoising faces critical challenges due to the compound mixed Poisson-Gaussian noise with strong spatial correlation and the impracticality of acquiring paired noisy/clean data in dynamic biomedical scenarios. While supervised methods trained on synthetic noise (e.g., Gaussian/Poisson) suffer from out-of-distribution generalization issues, existing self-supervised approaches degrade under real FMI noise due to oversimplified noise assumptions and computationally intensive deep architectures. In this paper, we propose Fluorescence Micrograph to Self (FM2S), a zero-shot denoiser that achieves efficient FMI denoising through three key innovations: 1) A noise injection module that ensures training data sufficiency through adaptive Poisson-Gaussian synthesis while preserving spatial correlation and global statistics of FMI noise for robust model generalization; 2) A two-stage progressive learning strategy that first recovers structural priors via pre-denoised targets then refines high-frequency details through noise distribution alignment; 3) An ultra-lightweight network (3.5k parameters) enabling rapid convergence with 270$\times$ faster training and inference than SOTAs. Extensive experiments across FMI datasets demonstrate FM2S's superiority: It outperforms CVF-SID by 1.4dB PSNR on average while requiring 0.1% parameters of AP-BSN. Notably, FM2S maintains stable performance across varying noise levels, proving its practicality for microscopy platforms with diverse sensor characteristics. Code and datasets will be released. |
| title | FM2S: Towards Spatially-Correlated Noise Modeling in Zero-Shot Fluorescence Microscopy Image Denoising |
| topic | Image and Video Processing Computer Vision and Pattern Recognition |
| url | https://arxiv.org/abs/2412.10031 |