Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies
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arXiv
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| Natura: | Preprint |
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2024
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| _version_ | 1866916538615857152 |
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| author | Shareef, T. H. Mohamed Ahadu Navabshan, Irfan Masood, M Mohamed Divan Yuvaraj, T. Eswara Sherif, A. |
| author_facet | Shareef, T. H. Mohamed Ahadu Navabshan, Irfan Masood, M Mohamed Divan Yuvaraj, T. Eswara Sherif, A. |
| contents | This study examines the phytochemical characteristics of Ayurvedic products. An analysis was performed on Kottakkal Ayurveda Triphala (T), Kottakkal Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J) using GC-MS and LC-MS techniques to determine their bioactive constituents, while also assessing their antimicrobial, docking, anticancer, and anti-diabetic activities. The GC-MS analysis identified 30, 45, and 8 chemical components in Kottakkal Ayurveda Triphala (T), Kottakkal Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J), respectively. The LC-MS analysis produced 15, 20, and 16 peaks for Kottakkal Ayurveda Triphala (T), Kottakkal Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J), with m/z values of 982, 981, 972, and 933; 987, 985, 974, and 945; and 969, 965, 951, and 941, respectively, confirming their precision. Moreover, characterization of the Ayurvedic products was carried out using FT-IR, UV-vis, and 1H-NMR spectroscopy to identify significant functional groups and chemical substances. Kottakkal Ayurveda Triphala (T) was evaluated for antibacterial activity against Gram-positive bacteria (Streptococcus pneumoniae and Staphylococcus aureus) along with Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae), yielding a P value of 0.0650 (P < 0.0001). Both Kottakkal Ayurveda Hinguvachadi Churnam (H) and Kottakkal Ayurveda Jirakadyarishtam (J) were subjected to analysis for their effectiveness against Aspergillus niger and Aspergillus fumigatus, also revealing a P value within the acceptable range of 0.0650 (P < 0.0001). The anti-diabetic properties of Kottakkal Ayurveda Triphala (T) were assessed using the α-glucosidase inhibitory method, which exhibited a significant inhibitory effect on α-glucosidase, resulting in an average P value of 0.001 (P < 0.0001). |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2412_17005 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies Shareef, T. H. Mohamed Ahadu Navabshan, Irfan Masood, M Mohamed Divan Yuvaraj, T. Eswara Sherif, A. Other Quantitative Biology 14J60 (Primary) 14F05, 14J26 (Secondary) F.2.2; I.2.7 This study examines the phytochemical characteristics of Ayurvedic products. An analysis was performed on Kottakkal Ayurveda Triphala (T), Kottakkal Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J) using GC-MS and LC-MS techniques to determine their bioactive constituents, while also assessing their antimicrobial, docking, anticancer, and anti-diabetic activities. The GC-MS analysis identified 30, 45, and 8 chemical components in Kottakkal Ayurveda Triphala (T), Kottakkal Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J), respectively. The LC-MS analysis produced 15, 20, and 16 peaks for Kottakkal Ayurveda Triphala (T), Kottakkal Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J), with m/z values of 982, 981, 972, and 933; 987, 985, 974, and 945; and 969, 965, 951, and 941, respectively, confirming their precision. Moreover, characterization of the Ayurvedic products was carried out using FT-IR, UV-vis, and 1H-NMR spectroscopy to identify significant functional groups and chemical substances. Kottakkal Ayurveda Triphala (T) was evaluated for antibacterial activity against Gram-positive bacteria (Streptococcus pneumoniae and Staphylococcus aureus) along with Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae), yielding a P value of 0.0650 (P < 0.0001). Both Kottakkal Ayurveda Hinguvachadi Churnam (H) and Kottakkal Ayurveda Jirakadyarishtam (J) were subjected to analysis for their effectiveness against Aspergillus niger and Aspergillus fumigatus, also revealing a P value within the acceptable range of 0.0650 (P < 0.0001). The anti-diabetic properties of Kottakkal Ayurveda Triphala (T) were assessed using the α-glucosidase inhibitory method, which exhibited a significant inhibitory effect on α-glucosidase, resulting in an average P value of 0.001 (P < 0.0001). |
| title | Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies |
| topic | Other Quantitative Biology 14J60 (Primary) 14F05, 14J26 (Secondary) F.2.2; I.2.7 |
| url | https://arxiv.org/abs/2412.17005 |