A Fluid-Structure Interaction Model of the Zebrafish Aortic Valve
Fuente:
arXiv
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2024
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866912440758829056 |
|---|---|
| author | Kaiser, Alexander D. Wang, Jing Brown, Aaron L. Zhu, Enbo Hsiai, Tzung Marsden, Alison L. |
| author_facet | Kaiser, Alexander D. Wang, Jing Brown, Aaron L. Zhu, Enbo Hsiai, Tzung Marsden, Alison L. |
| contents | The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics and anatomy with humans and ease of experimental manipulations. Computational fluid-structure interaction (FSI) simulations are an efficient and highly controllable means to study the function of cardiac valves in development and diseases. Due to their small scales, little is known about the mechanical properties of zebrafish cardiac valves, limiting existing computational studies of zebrafish valves and their interaction with blood. To circumvent these limitations, we took a largely first-principles approach called design-based elasticity that allows us to derive valve geometry, fiber orientation and material properties. In FSI simulations of an adult zebrafish aortic valve, these models produce realistic flow rates when driven by physiological pressures and demonstrate the spatiotemporal dynamics of valvular mechanical properties. These models can be used for future studies of zebrafish cardiac hemodynamics, development, and disease. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2412_18056 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | A Fluid-Structure Interaction Model of the Zebrafish Aortic Valve Kaiser, Alexander D. Wang, Jing Brown, Aaron L. Zhu, Enbo Hsiai, Tzung Marsden, Alison L. Tissues and Organs 92C35 (Primary), 92C10, 76Z05 (Secondary) J.3.1 The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics and anatomy with humans and ease of experimental manipulations. Computational fluid-structure interaction (FSI) simulations are an efficient and highly controllable means to study the function of cardiac valves in development and diseases. Due to their small scales, little is known about the mechanical properties of zebrafish cardiac valves, limiting existing computational studies of zebrafish valves and their interaction with blood. To circumvent these limitations, we took a largely first-principles approach called design-based elasticity that allows us to derive valve geometry, fiber orientation and material properties. In FSI simulations of an adult zebrafish aortic valve, these models produce realistic flow rates when driven by physiological pressures and demonstrate the spatiotemporal dynamics of valvular mechanical properties. These models can be used for future studies of zebrafish cardiac hemodynamics, development, and disease. |
| title | A Fluid-Structure Interaction Model of the Zebrafish Aortic Valve |
| topic | Tissues and Organs 92C35 (Primary), 92C10, 76Z05 (Secondary) J.3.1 |
| url | https://arxiv.org/abs/2412.18056 |