Biological Insights from Integrative Modeling of Intrinsically Disordered Protein Systems
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arXiv
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| Main Authors: | , , , , |
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| Format: | Preprint |
| Published: |
2024
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| Subjects: | |
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| _version_ | 1866915081837608960 |
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| author | Liu, Zi Hao Tsanai, Maria Zhang, Oufan Head-Gordon, Teresa Forman-Kay, Julie |
| author_facet | Liu, Zi Hao Tsanai, Maria Zhang, Oufan Head-Gordon, Teresa Forman-Kay, Julie |
| contents | Intrinsically disordered proteins and regions are increasingly appreciated for their abundance in the proteome and the many functional roles they play in the cell. In this short review, we describe a variety of approaches used to obtain biological insight from the structural ensembles of disordered proteins, regions, and complexes and the integrative biology challenges that arise from combining diverse experiments and computational models. Importantly, we highlight findings regarding structural and dynamic characterization of disordered regions involved in binding and phase separation, as well as drug targeting of disordered regions, using a broad framework of integrative modeling approaches. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2412_19875 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Biological Insights from Integrative Modeling of Intrinsically Disordered Protein Systems Liu, Zi Hao Tsanai, Maria Zhang, Oufan Head-Gordon, Teresa Forman-Kay, Julie Biological Physics Biomolecules Intrinsically disordered proteins and regions are increasingly appreciated for their abundance in the proteome and the many functional roles they play in the cell. In this short review, we describe a variety of approaches used to obtain biological insight from the structural ensembles of disordered proteins, regions, and complexes and the integrative biology challenges that arise from combining diverse experiments and computational models. Importantly, we highlight findings regarding structural and dynamic characterization of disordered regions involved in binding and phase separation, as well as drug targeting of disordered regions, using a broad framework of integrative modeling approaches. |
| title | Biological Insights from Integrative Modeling of Intrinsically Disordered Protein Systems |
| topic | Biological Physics Biomolecules |
| url | https://arxiv.org/abs/2412.19875 |