3D Single-shot CEST imaging at 3T Based on True FISP Readout
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arXiv
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2025
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| _version_ | 1866912503474159616 |
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| author | Wu, Yupeng Pang, Qifan Wang, Zhichao Li, Gaiying Fu, Caixia Cao, Mengqiu Wang, Xingrui Jiang, Dongmei She, Dejun Song, Yang Zhao, Yu Li, Jianqi |
| author_facet | Wu, Yupeng Pang, Qifan Wang, Zhichao Li, Gaiying Fu, Caixia Cao, Mengqiu Wang, Xingrui Jiang, Dongmei She, Dejun Song, Yang Zhao, Yu Li, Jianqi |
| contents | To simultaneously fit multiple-pool effects, spectrally selective 3D CEST imaging typically requires single-shot readouts to save time. However, to date, FLASH and EPI have been the primary pulse sequences used for this purpose. They suffer from low SNR or image distortion related to B0 field inhomogeneity. In this work, we developed a 3D single-shot CEST sequence using true fast imaging with steady-state precession (True FISP) readout, also known as bSSFP, and optimized the scanning parameters through simulations. The performance of the CEST sequence was validated using an egg white phantom, ten healthy volunteers, and a patient with a brain tumor on a 3T human scanner. Subsequently, the proposed CEST sequence using True FISP was compared with the commonly used FLASH-based CEST sequence, focusing on SNR and image contrast, while maintaining identical pre-saturation modes, repetition time, echo time and scan time. In the simulation experiments, the maximum CEST signal obtained from the True FISP was significantly greater than that obtained from the FLASH sequence. In the egg white phantom, the SNRs of amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) effect images obtained from the True FISP were 68.3% and 57.0% higher than those obtained from the FLASH sequence, respectively. In healthy volunteers, saturated images collected with the True FISP sequence at 3.5 ppm showed an approximate 84% increase in mean temporal SNR compared to those collected with the FLASH sequence. Compared to the FLASH sequence, the CEST images obtained from the True FISP sequence could display more detailed brain tissue structures of both normal individuals and the patient with a brain tumor. Therefore, due to the high SNR inherent in the sequence, True FISP has the potential to be used for fast and high-quality 3D image readout of CEST contrasts in clinical applications. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2501_03548 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | 3D Single-shot CEST imaging at 3T Based on True FISP Readout Wu, Yupeng Pang, Qifan Wang, Zhichao Li, Gaiying Fu, Caixia Cao, Mengqiu Wang, Xingrui Jiang, Dongmei She, Dejun Song, Yang Zhao, Yu Li, Jianqi Medical Physics To simultaneously fit multiple-pool effects, spectrally selective 3D CEST imaging typically requires single-shot readouts to save time. However, to date, FLASH and EPI have been the primary pulse sequences used for this purpose. They suffer from low SNR or image distortion related to B0 field inhomogeneity. In this work, we developed a 3D single-shot CEST sequence using true fast imaging with steady-state precession (True FISP) readout, also known as bSSFP, and optimized the scanning parameters through simulations. The performance of the CEST sequence was validated using an egg white phantom, ten healthy volunteers, and a patient with a brain tumor on a 3T human scanner. Subsequently, the proposed CEST sequence using True FISP was compared with the commonly used FLASH-based CEST sequence, focusing on SNR and image contrast, while maintaining identical pre-saturation modes, repetition time, echo time and scan time. In the simulation experiments, the maximum CEST signal obtained from the True FISP was significantly greater than that obtained from the FLASH sequence. In the egg white phantom, the SNRs of amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) effect images obtained from the True FISP were 68.3% and 57.0% higher than those obtained from the FLASH sequence, respectively. In healthy volunteers, saturated images collected with the True FISP sequence at 3.5 ppm showed an approximate 84% increase in mean temporal SNR compared to those collected with the FLASH sequence. Compared to the FLASH sequence, the CEST images obtained from the True FISP sequence could display more detailed brain tissue structures of both normal individuals and the patient with a brain tumor. Therefore, due to the high SNR inherent in the sequence, True FISP has the potential to be used for fast and high-quality 3D image readout of CEST contrasts in clinical applications. |
| title | 3D Single-shot CEST imaging at 3T Based on True FISP Readout |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2501.03548 |