Enhancing kidney quality assessment: Power Doppler during normothermic machine perfusion
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| Format: | Preprint |
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2025
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| _version_ | 1866915196957622272 |
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| author | Fang, Yitian Nikolaev, Anton V. Essers, Jeroen Ambagtsheer, Gisela Groningen, Marian C. Clahsen-van Minnee, Robert C. de Bruin, Ron W. F. van Soest, Gijs |
| author_facet | Fang, Yitian Nikolaev, Anton V. Essers, Jeroen Ambagtsheer, Gisela Groningen, Marian C. Clahsen-van Minnee, Robert C. de Bruin, Ron W. F. van Soest, Gijs |
| contents | Objectives: Marginal donor kidneys are increasingly used for transplantation to overcome organ shortage. This study aims to investigate the additional value of Power Doppler (PD) imaging in kidney quality assessment during normothermic machine perfusion (NMP). Methods: Porcine kidneys (n=22) retrieved from a local slaughterhouse underwent 2 hours of NMP. Based on creatinine clearance (CrCl) and oxygen consumption (VO2), the kidneys were classified as functional (n=7) and non-functional (n=15) kidneys. PD imaging was performed at 30, 60, and 120 minutes, and PD metrics, including vascularization index (VI), flow index (FI), and vascularization flow index (VFI) were calculated. Renal blood flow (RBF), CrCl, and VO2 were measured at the same time points during NMP. The metrics were compared utilizing correlation analysis. Results: FI and VFI moderately correlated with CrCl (r=0.537, p<0.0001; r=0.536, p<0.0001, respectively), while VI strongly correlated with VO2 (r=0.839, p<0.0001). At 120 minutes, PD metrics demonstrated the highest diagnostic accuracy for distinguishing functional from non-functional kidneys, with an area under the curve (AUC) of 0.943 for VI, 0.924 for FI, and 0.943 for VFI. Cutoff values of 17% for VI, 50 a.u. for FI, and 9 a.u. for VFI provided 100% specificity and 73% sensitivity to identify non-functional kidneys, with an overall diagnostic accuracy of 82%. Baseline kidney biopsies showed moderate acute tubular necrosis in both groups with no significant differences. Conclusions: PD metrics strongly correlate with renal viability and effectively differentiate functional from non-functional kidneys. PD imaging can be a valuable alternative to RBF during NMP for kidney assessment. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2501_04457 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Enhancing kidney quality assessment: Power Doppler during normothermic machine perfusion Fang, Yitian Nikolaev, Anton V. Essers, Jeroen Ambagtsheer, Gisela Groningen, Marian C. Clahsen-van Minnee, Robert C. de Bruin, Ron W. F. van Soest, Gijs Medical Physics Biological Physics Objectives: Marginal donor kidneys are increasingly used for transplantation to overcome organ shortage. This study aims to investigate the additional value of Power Doppler (PD) imaging in kidney quality assessment during normothermic machine perfusion (NMP). Methods: Porcine kidneys (n=22) retrieved from a local slaughterhouse underwent 2 hours of NMP. Based on creatinine clearance (CrCl) and oxygen consumption (VO2), the kidneys were classified as functional (n=7) and non-functional (n=15) kidneys. PD imaging was performed at 30, 60, and 120 minutes, and PD metrics, including vascularization index (VI), flow index (FI), and vascularization flow index (VFI) were calculated. Renal blood flow (RBF), CrCl, and VO2 were measured at the same time points during NMP. The metrics were compared utilizing correlation analysis. Results: FI and VFI moderately correlated with CrCl (r=0.537, p<0.0001; r=0.536, p<0.0001, respectively), while VI strongly correlated with VO2 (r=0.839, p<0.0001). At 120 minutes, PD metrics demonstrated the highest diagnostic accuracy for distinguishing functional from non-functional kidneys, with an area under the curve (AUC) of 0.943 for VI, 0.924 for FI, and 0.943 for VFI. Cutoff values of 17% for VI, 50 a.u. for FI, and 9 a.u. for VFI provided 100% specificity and 73% sensitivity to identify non-functional kidneys, with an overall diagnostic accuracy of 82%. Baseline kidney biopsies showed moderate acute tubular necrosis in both groups with no significant differences. Conclusions: PD metrics strongly correlate with renal viability and effectively differentiate functional from non-functional kidneys. PD imaging can be a valuable alternative to RBF during NMP for kidney assessment. |
| title | Enhancing kidney quality assessment: Power Doppler during normothermic machine perfusion |
| topic | Medical Physics Biological Physics |
| url | https://arxiv.org/abs/2501.04457 |