A phase-field model for solutions of DNA-made particles
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arXiv
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| Auteurs principaux: | , , |
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| Format: | Preprint |
| Publié: |
2025
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| _version_ | 1866908330836885504 |
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| author | Cappa, Marco Sciortino, Francesco Rovigatti, Lorenzo |
| author_facet | Cappa, Marco Sciortino, Francesco Rovigatti, Lorenzo |
| contents | We present a phase-field model based on the Cahn-Hilliard equation to investigate the properties of phase separation in DNA nanostar systems. Leveraging a realistic free-energy functional derived from Wertheim theory, our model captures the thermodynamic properties of self-assembling DNA nanostars under various conditions. This approach allows for the study of both one-component and multi-component systems, including mixtures of different nanostar species and cross-linkers. Through numerical simulations, we demonstrate the model ability to replicate experimental observations, including liquid-liquid phase separation, surface tension variation, and the structural organisation of multi-component systems. Our results highlight the versatility and predictive power of the Cahn-Hilliard framework, particularly for complex systems where detailed simulations are computationally prohibitive. This work provides a robust foundation for studying DNA-based materials and their potential applications in nanotechnology and biophysics, including liquid-liquid phase separation in cellular environments. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2501_04790 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | A phase-field model for solutions of DNA-made particles Cappa, Marco Sciortino, Francesco Rovigatti, Lorenzo Soft Condensed Matter We present a phase-field model based on the Cahn-Hilliard equation to investigate the properties of phase separation in DNA nanostar systems. Leveraging a realistic free-energy functional derived from Wertheim theory, our model captures the thermodynamic properties of self-assembling DNA nanostars under various conditions. This approach allows for the study of both one-component and multi-component systems, including mixtures of different nanostar species and cross-linkers. Through numerical simulations, we demonstrate the model ability to replicate experimental observations, including liquid-liquid phase separation, surface tension variation, and the structural organisation of multi-component systems. Our results highlight the versatility and predictive power of the Cahn-Hilliard framework, particularly for complex systems where detailed simulations are computationally prohibitive. This work provides a robust foundation for studying DNA-based materials and their potential applications in nanotechnology and biophysics, including liquid-liquid phase separation in cellular environments. |
| title | A phase-field model for solutions of DNA-made particles |
| topic | Soft Condensed Matter |
| url | https://arxiv.org/abs/2501.04790 |