Clinically Ready Magnetic Microrobots for Targeted Therapies
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arXiv
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866911290973224960 |
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| author | Landers, Fabian C. Hertle, Lukas Pustovalov, Vitaly Sivakumaran, Derick Brinkmann, Oliver Meiners, Kirstin Theiler, Pascal Gantenbein, Valentin Veciana, Andrea Mattmann, Michael Riss, Silas Gervasoni, Simone Chautems, Christophe Ye, Hao Sevim, Semih Flouris, Andreas D. Puigmartí-Luis, Josep Mayor, Tiago Sotto Alves, Pedro Lühmann, Tessa Chen, Xiangzhong Ochsenbein, Nicole Moehrlen, Ueli Gruber, Philipp Weisskopf, Miriam Boehler, Quentin Pané, Salvador Nelson, Bradley J. |
| author_facet | Landers, Fabian C. Hertle, Lukas Pustovalov, Vitaly Sivakumaran, Derick Brinkmann, Oliver Meiners, Kirstin Theiler, Pascal Gantenbein, Valentin Veciana, Andrea Mattmann, Michael Riss, Silas Gervasoni, Simone Chautems, Christophe Ye, Hao Sevim, Semih Flouris, Andreas D. Puigmartí-Luis, Josep Mayor, Tiago Sotto Alves, Pedro Lühmann, Tessa Chen, Xiangzhong Ochsenbein, Nicole Moehrlen, Ueli Gruber, Philipp Weisskopf, Miriam Boehler, Quentin Pané, Salvador Nelson, Bradley J. |
| contents | Systemic drug administration often causes off-target effects limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a magnetically guided microrobotic drug delivery system capable of precise navigation under physiological conditions. This platform integrates a clinical electromagnetic navigation system, a custom-designed release catheter, and a dissolvable capsule for accurate therapeutic delivery. In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models. The microrobot balances magnetic material concentration, contrast agent loading, and therapeutic drug capacity, enabling effective hosting of therapeutics despite the integration complexity of its components, offering a promising solution for precise targeted drug delivery. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2501_11553 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Clinically Ready Magnetic Microrobots for Targeted Therapies Landers, Fabian C. Hertle, Lukas Pustovalov, Vitaly Sivakumaran, Derick Brinkmann, Oliver Meiners, Kirstin Theiler, Pascal Gantenbein, Valentin Veciana, Andrea Mattmann, Michael Riss, Silas Gervasoni, Simone Chautems, Christophe Ye, Hao Sevim, Semih Flouris, Andreas D. Puigmartí-Luis, Josep Mayor, Tiago Sotto Alves, Pedro Lühmann, Tessa Chen, Xiangzhong Ochsenbein, Nicole Moehrlen, Ueli Gruber, Philipp Weisskopf, Miriam Boehler, Quentin Pané, Salvador Nelson, Bradley J. Robotics Materials Science Systems and Control Applied Physics Biological Physics Medical Physics Systemic drug administration often causes off-target effects limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a magnetically guided microrobotic drug delivery system capable of precise navigation under physiological conditions. This platform integrates a clinical electromagnetic navigation system, a custom-designed release catheter, and a dissolvable capsule for accurate therapeutic delivery. In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models. The microrobot balances magnetic material concentration, contrast agent loading, and therapeutic drug capacity, enabling effective hosting of therapeutics despite the integration complexity of its components, offering a promising solution for precise targeted drug delivery. |
| title | Clinically Ready Magnetic Microrobots for Targeted Therapies |
| topic | Robotics Materials Science Systems and Control Applied Physics Biological Physics Medical Physics |
| url | https://arxiv.org/abs/2501.11553 |