Automatic detection and prediction of nAMD activity change in retinal OCT using Siamese networks and Wasserstein Distance for ordinality
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| Main Authors: | , , , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866917901661896704 |
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| author | Emre, Taha Araújo, Teresa Oghbaie, Marzieh Lachinov, Dmitrii Aresta, Guilherme Bogunović, Hrvoje |
| author_facet | Emre, Taha Araújo, Teresa Oghbaie, Marzieh Lachinov, Dmitrii Aresta, Guilherme Bogunović, Hrvoje |
| contents | Neovascular age-related macular degeneration (nAMD) is a leading cause of vision loss among older adults, where disease activity detection and progression prediction are critical for nAMD management in terms of timely drug administration and improving patient outcomes. Recent advancements in deep learning offer a promising solution for predicting changes in AMD from optical coherence tomography (OCT) retinal volumes. In this work, we proposed deep learning models for the two tasks of the public MARIO Challenge at MICCAI 2024, designed to detect and forecast changes in nAMD severity with longitudinal retinal OCT. For the first task, we employ a Vision Transformer (ViT) based Siamese Network to detect changes in AMD severity by comparing scan embeddings of a patient from different time points. To train a model to forecast the change after 3 months, we exploit, for the first time, an Earth Mover (Wasserstein) Distance-based loss to harness the ordinal relation within the severity change classes. Both models ranked high on the preliminary leaderboard, demonstrating that their predictive capabilities could facilitate nAMD treatment management. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2501_14323 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Automatic detection and prediction of nAMD activity change in retinal OCT using Siamese networks and Wasserstein Distance for ordinality Emre, Taha Araújo, Teresa Oghbaie, Marzieh Lachinov, Dmitrii Aresta, Guilherme Bogunović, Hrvoje Image and Video Processing Computer Vision and Pattern Recognition Machine Learning Neovascular age-related macular degeneration (nAMD) is a leading cause of vision loss among older adults, where disease activity detection and progression prediction are critical for nAMD management in terms of timely drug administration and improving patient outcomes. Recent advancements in deep learning offer a promising solution for predicting changes in AMD from optical coherence tomography (OCT) retinal volumes. In this work, we proposed deep learning models for the two tasks of the public MARIO Challenge at MICCAI 2024, designed to detect and forecast changes in nAMD severity with longitudinal retinal OCT. For the first task, we employ a Vision Transformer (ViT) based Siamese Network to detect changes in AMD severity by comparing scan embeddings of a patient from different time points. To train a model to forecast the change after 3 months, we exploit, for the first time, an Earth Mover (Wasserstein) Distance-based loss to harness the ordinal relation within the severity change classes. Both models ranked high on the preliminary leaderboard, demonstrating that their predictive capabilities could facilitate nAMD treatment management. |
| title | Automatic detection and prediction of nAMD activity change in retinal OCT using Siamese networks and Wasserstein Distance for ordinality |
| topic | Image and Video Processing Computer Vision and Pattern Recognition Machine Learning |
| url | https://arxiv.org/abs/2501.14323 |