Earth, a planetary PCR machine to create life, or the brief history of a tRNA
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arXiv
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| Format: | Preprint |
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2025
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| _version_ | 1866916581817188352 |
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| author | Jimenez, Juan |
| author_facet | Jimenez, Juan |
| contents | About 4 billion years ago, the Earth probably fulfilled the environmental conditions necessary to favour the transition from primitive chemistry to life. Based on a theoretical hairpin duplication origin of tRNAs and their putative peptide-coding capability before ribosomes existed, here I postulate that, at this hypothetical environment, Earth's daily temperature cycles could have provided a unique planetary thermocycler to create self-replicating RNA hairpins that simultaneously templated amino acids polymerization in a primordial PCR well of prebiotic molecules. This early RNA hairpin-peptide interaction could have established a reciprocal nucleopeptide replicator that paved the way for catalytic translation and replication machineries towards the origin of LUCA. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2501_14436 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Earth, a planetary PCR machine to create life, or the brief history of a tRNA Jimenez, Juan Biological Physics Populations and Evolution 92D15 About 4 billion years ago, the Earth probably fulfilled the environmental conditions necessary to favour the transition from primitive chemistry to life. Based on a theoretical hairpin duplication origin of tRNAs and their putative peptide-coding capability before ribosomes existed, here I postulate that, at this hypothetical environment, Earth's daily temperature cycles could have provided a unique planetary thermocycler to create self-replicating RNA hairpins that simultaneously templated amino acids polymerization in a primordial PCR well of prebiotic molecules. This early RNA hairpin-peptide interaction could have established a reciprocal nucleopeptide replicator that paved the way for catalytic translation and replication machineries towards the origin of LUCA. |
| title | Earth, a planetary PCR machine to create life, or the brief history of a tRNA |
| topic | Biological Physics Populations and Evolution 92D15 |
| url | https://arxiv.org/abs/2501.14436 |