Deep generative computed perfusion-deficit mapping of ischaemic stroke
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| Main Authors: | , , , , , , , , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866912932921606144 |
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| author | Tangwiriyasakul, Chayanin Borges, Pedro Pombo, Guilherme Moriconi, Stefano Elmalem, Michael S. Wright, Paul Mah, Yee-Haur Rondina, Jane Ourselin, Sebastien Nachev, Parashkev Cardoso, M. Jorge |
| author_facet | Tangwiriyasakul, Chayanin Borges, Pedro Pombo, Guilherme Moriconi, Stefano Elmalem, Michael S. Wright, Paul Mah, Yee-Haur Rondina, Jane Ourselin, Sebastien Nachev, Parashkev Cardoso, M. Jorge |
| contents | Focal deficits in ischaemic stroke result from impaired perfusion downstream of a critical vascular occlusion. While parenchymal lesions are traditionally used to predict clinical deficits, the underlying pattern of disrupted perfusion provides information upstream of the lesion, potentially yielding earlier predictive and localizing signals. Such perfusion maps can be derived from routine CT angiography (CTA) widely deployed in clinical practice. Analysing computed perfusion maps from 1,393 CTA-imaged-patients with acute ischaemic stroke, we use deep generative inference to localise neural substrates of NIHSS sub-scores. We show that our approach replicates known lesion-deficit relations without knowledge of the lesion itself and reveals novel neural dependents. The high achieved anatomical fidelity suggests acute CTA-derived computed perfusion maps may be of substantial clinical-and-scientific value in rich phenotyping of acute stroke. Using only hyperacute imaging, deep generative inference could power highly expressive models of functional anatomical relations in ischaemic stroke within the pre-interventional window. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2502_01334 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Deep generative computed perfusion-deficit mapping of ischaemic stroke Tangwiriyasakul, Chayanin Borges, Pedro Pombo, Guilherme Moriconi, Stefano Elmalem, Michael S. Wright, Paul Mah, Yee-Haur Rondina, Jane Ourselin, Sebastien Nachev, Parashkev Cardoso, M. Jorge Quantitative Methods Computer Vision and Pattern Recognition Neurons and Cognition Focal deficits in ischaemic stroke result from impaired perfusion downstream of a critical vascular occlusion. While parenchymal lesions are traditionally used to predict clinical deficits, the underlying pattern of disrupted perfusion provides information upstream of the lesion, potentially yielding earlier predictive and localizing signals. Such perfusion maps can be derived from routine CT angiography (CTA) widely deployed in clinical practice. Analysing computed perfusion maps from 1,393 CTA-imaged-patients with acute ischaemic stroke, we use deep generative inference to localise neural substrates of NIHSS sub-scores. We show that our approach replicates known lesion-deficit relations without knowledge of the lesion itself and reveals novel neural dependents. The high achieved anatomical fidelity suggests acute CTA-derived computed perfusion maps may be of substantial clinical-and-scientific value in rich phenotyping of acute stroke. Using only hyperacute imaging, deep generative inference could power highly expressive models of functional anatomical relations in ischaemic stroke within the pre-interventional window. |
| title | Deep generative computed perfusion-deficit mapping of ischaemic stroke |
| topic | Quantitative Methods Computer Vision and Pattern Recognition Neurons and Cognition |
| url | https://arxiv.org/abs/2502.01334 |