Spatial-offset pump-probe imaging of nonradiative dynamics at optical resolution
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arXiv
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| Format: | Preprint |
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2025
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| _version_ | 1866909483636097024 |
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| author | Chen, Guo Yuan, Yuhao Ni, Hongli Ding, Guangrui Li, Mingsheng Zhu, Yifan Li, Deming Zeng, Hongru He, Hongjian Guo, Zhongyue Cheng, Ji-Xin Yang, Chen |
| author_facet | Chen, Guo Yuan, Yuhao Ni, Hongli Ding, Guangrui Li, Mingsheng Zhu, Yifan Li, Deming Zeng, Hongru He, Hongjian Guo, Zhongyue Cheng, Ji-Xin Yang, Chen |
| contents | Nonradiative photothermal (PT) and photoacoustic (PA) processes have found widespread applications in imaging, stimulation, and therapy. Mapping the generation and propagation of PA and PT waves with resolution is important to elucidate how these fields interact with biological systems. To this end, we introduce spatial offset pump-probe imaging (SOPPI). By spatially offsetting the pump beam and the probe beam, SOPPI can image simultaneously PA and PT wave propagation with nanosecond temporal resolution, micrometer spatial resolution, 65 MHz detection bandwidth, and a sensitivity of 9.9 Pa noise equivalent pressure. We first map the PA and PT evolution from a fiber emitter, and how the wave interacting with a mouse skull and brain slices. SOPPI imaging of PA waves from a tapered fiber with water as an absorber shows a wavelength-dependent generation, evanescent wave generated PA, and back-propagated acoustic Mach Cone. At last, a SOPPI-PACT is developed to reconstruct the pigment distribution inside a zebrafish larva with high precision and signal-to-noise ratio. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_03384 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Spatial-offset pump-probe imaging of nonradiative dynamics at optical resolution Chen, Guo Yuan, Yuhao Ni, Hongli Ding, Guangrui Li, Mingsheng Zhu, Yifan Li, Deming Zeng, Hongru He, Hongjian Guo, Zhongyue Cheng, Ji-Xin Yang, Chen Optics Applied Physics Nonradiative photothermal (PT) and photoacoustic (PA) processes have found widespread applications in imaging, stimulation, and therapy. Mapping the generation and propagation of PA and PT waves with resolution is important to elucidate how these fields interact with biological systems. To this end, we introduce spatial offset pump-probe imaging (SOPPI). By spatially offsetting the pump beam and the probe beam, SOPPI can image simultaneously PA and PT wave propagation with nanosecond temporal resolution, micrometer spatial resolution, 65 MHz detection bandwidth, and a sensitivity of 9.9 Pa noise equivalent pressure. We first map the PA and PT evolution from a fiber emitter, and how the wave interacting with a mouse skull and brain slices. SOPPI imaging of PA waves from a tapered fiber with water as an absorber shows a wavelength-dependent generation, evanescent wave generated PA, and back-propagated acoustic Mach Cone. At last, a SOPPI-PACT is developed to reconstruct the pigment distribution inside a zebrafish larva with high precision and signal-to-noise ratio. |
| title | Spatial-offset pump-probe imaging of nonradiative dynamics at optical resolution |
| topic | Optics Applied Physics |
| url | https://arxiv.org/abs/2502.03384 |