Synthetic Poisoning Attacks: The Impact of Poisoned MRI Image on U-Net Brain Tumor Segmentation
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arXiv
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| Main Authors: | , , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866913681331191808 |
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| author | Li, Tianhao Zeng, Tianyu Zheng, Yujia Zhang, Chulong Lu, Jingyu Huang, Haotian Chu, Chuangxin Yin, Fang-Fang Yang, Zhenyu |
| author_facet | Li, Tianhao Zeng, Tianyu Zheng, Yujia Zhang, Chulong Lu, Jingyu Huang, Haotian Chu, Chuangxin Yin, Fang-Fang Yang, Zhenyu |
| contents | Deep learning-based medical image segmentation models, such as U-Net, rely on high-quality annotated datasets to achieve accurate predictions. However, the increasing use of generative models for synthetic data augmentation introduces potential risks, particularly in the absence of rigorous quality control. In this paper, we investigate the impact of synthetic MRI data on the robustness and segmentation accuracy of U-Net models for brain tumor segmentation. Specifically, we generate synthetic T1-contrast-enhanced (T1-Ce) MRI scans using a GAN-based model with a shared encoding-decoding framework and shortest-path regularization. To quantify the effect of synthetic data contamination, we train U-Net models on progressively "poisoned" datasets, where synthetic data proportions range from 16.67% to 83.33%. Experimental results on a real MRI validation set reveal a significant performance degradation as synthetic data increases, with Dice coefficients dropping from 0.8937 (33.33% synthetic) to 0.7474 (83.33% synthetic). Accuracy and sensitivity exhibit similar downward trends, demonstrating the detrimental effect of synthetic data on segmentation robustness. These findings underscore the importance of quality control in synthetic data integration and highlight the risks of unregulated synthetic augmentation in medical image analysis. Our study provides critical insights for the development of more reliable and trustworthy AI-driven medical imaging systems. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_03825 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Synthetic Poisoning Attacks: The Impact of Poisoned MRI Image on U-Net Brain Tumor Segmentation Li, Tianhao Zeng, Tianyu Zheng, Yujia Zhang, Chulong Lu, Jingyu Huang, Haotian Chu, Chuangxin Yin, Fang-Fang Yang, Zhenyu Image and Video Processing Cryptography and Security Computer Vision and Pattern Recognition Deep learning-based medical image segmentation models, such as U-Net, rely on high-quality annotated datasets to achieve accurate predictions. However, the increasing use of generative models for synthetic data augmentation introduces potential risks, particularly in the absence of rigorous quality control. In this paper, we investigate the impact of synthetic MRI data on the robustness and segmentation accuracy of U-Net models for brain tumor segmentation. Specifically, we generate synthetic T1-contrast-enhanced (T1-Ce) MRI scans using a GAN-based model with a shared encoding-decoding framework and shortest-path regularization. To quantify the effect of synthetic data contamination, we train U-Net models on progressively "poisoned" datasets, where synthetic data proportions range from 16.67% to 83.33%. Experimental results on a real MRI validation set reveal a significant performance degradation as synthetic data increases, with Dice coefficients dropping from 0.8937 (33.33% synthetic) to 0.7474 (83.33% synthetic). Accuracy and sensitivity exhibit similar downward trends, demonstrating the detrimental effect of synthetic data on segmentation robustness. These findings underscore the importance of quality control in synthetic data integration and highlight the risks of unregulated synthetic augmentation in medical image analysis. Our study provides critical insights for the development of more reliable and trustworthy AI-driven medical imaging systems. |
| title | Synthetic Poisoning Attacks: The Impact of Poisoned MRI Image on U-Net Brain Tumor Segmentation |
| topic | Image and Video Processing Cryptography and Security Computer Vision and Pattern Recognition |
| url | https://arxiv.org/abs/2502.03825 |