Stochastic Kinetics of mRNA Molecules in a General Transcription Model
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arXiv
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| Natura: | Preprint |
| Pubblicazione: |
2025
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| _version_ | 1866912707406462976 |
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| author | Lu, Yuntao Zhang, Yunxin |
| author_facet | Lu, Yuntao Zhang, Yunxin |
| contents | Stochastic modeling of transcription is a classic yet long-standing problem in theoretical biophysics. The lack of unified results and a computationally efficient approach for a general, fine-grained transcription model has confined relevant research to some over-simplified special cases like the Telegraph model. This article establishes a general, unified and computationally efficient framework for studying stochastic transcription kinetics. We consider a chemical reaction model of transcription and construct the time-dependent solution to the corresponding chemical master equation. A well-known matrix-form expression for steady-state binomial moments is recovered by calculating the temporal limit of the time-dependent dynamics. Two novel inequalities for binomial moments and the probability mass function are derived using techniques from functional analysis. It follows that the distribution of mRNA counts is upper-bounded by a constant multiple of Poisson distribution, thus mathematically proving the main statement of the Heavy-Tailed Law. Additionally, the standard binomial moment method is analyzed from a numerical perspective, where truncation error is estimated using our inequalities. Compared with some widely-used numerical methods, a key advantage of this result is the significantly lower computational complexity. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_08028 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Stochastic Kinetics of mRNA Molecules in a General Transcription Model Lu, Yuntao Zhang, Yunxin Biological Physics 60J28 Stochastic modeling of transcription is a classic yet long-standing problem in theoretical biophysics. The lack of unified results and a computationally efficient approach for a general, fine-grained transcription model has confined relevant research to some over-simplified special cases like the Telegraph model. This article establishes a general, unified and computationally efficient framework for studying stochastic transcription kinetics. We consider a chemical reaction model of transcription and construct the time-dependent solution to the corresponding chemical master equation. A well-known matrix-form expression for steady-state binomial moments is recovered by calculating the temporal limit of the time-dependent dynamics. Two novel inequalities for binomial moments and the probability mass function are derived using techniques from functional analysis. It follows that the distribution of mRNA counts is upper-bounded by a constant multiple of Poisson distribution, thus mathematically proving the main statement of the Heavy-Tailed Law. Additionally, the standard binomial moment method is analyzed from a numerical perspective, where truncation error is estimated using our inequalities. Compared with some widely-used numerical methods, a key advantage of this result is the significantly lower computational complexity. |
| title | Stochastic Kinetics of mRNA Molecules in a General Transcription Model |
| topic | Biological Physics 60J28 |
| url | https://arxiv.org/abs/2502.08028 |