Thiolation and PEGylation of silicon carbide nanoparticle
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arXiv
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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866909604071342080 |
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| author | Rózsa, Péter Krafcsik, Olga Czigány, Zsolt Lenk, Sándor Beke, David Gali, Adam |
| author_facet | Rózsa, Péter Krafcsik, Olga Czigány, Zsolt Lenk, Sándor Beke, David Gali, Adam |
| contents | In this study, we implement thiol termination on the surface of few-nanometer-sized silicon carbide (SiC) nanoparticles (NPs) to enable further applications, such as fluorescent biomarkers. Various spectroscopic techniques are employed to monitor the effectiveness of the surface treatment. A thiol-Michael addition reaction is performed by conjugating 4-arm PEGmaleimide molecules to the thiol groups of SiC NPs, further demonstrating the reactivity of thiol-terminated SiC NPs, which also acts as a protection layer against oxidation. These fluorescent thiolated SiC NPs, both with and without conjugated molecules, are directly applicable as bioinert probes. Since SiC NPs can potentially host room-temperature fluorescent defect quantum bits, our results are an important step to realize a bioinert, ultrasmall quantum sensor bioagents, which may open new avenues in biotechnology. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_08469 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Thiolation and PEGylation of silicon carbide nanoparticle Rózsa, Péter Krafcsik, Olga Czigány, Zsolt Lenk, Sándor Beke, David Gali, Adam Materials Science In this study, we implement thiol termination on the surface of few-nanometer-sized silicon carbide (SiC) nanoparticles (NPs) to enable further applications, such as fluorescent biomarkers. Various spectroscopic techniques are employed to monitor the effectiveness of the surface treatment. A thiol-Michael addition reaction is performed by conjugating 4-arm PEGmaleimide molecules to the thiol groups of SiC NPs, further demonstrating the reactivity of thiol-terminated SiC NPs, which also acts as a protection layer against oxidation. These fluorescent thiolated SiC NPs, both with and without conjugated molecules, are directly applicable as bioinert probes. Since SiC NPs can potentially host room-temperature fluorescent defect quantum bits, our results are an important step to realize a bioinert, ultrasmall quantum sensor bioagents, which may open new avenues in biotechnology. |
| title | Thiolation and PEGylation of silicon carbide nanoparticle |
| topic | Materials Science |
| url | https://arxiv.org/abs/2502.08469 |