A Survey on Human-Centered Evaluation of Explainable AI Methods in Clinical Decision Support Systems

Fuente: arXiv
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Hauptverfasser: Gambetti, Alessandro, Han, Qiwei, Shen, Hong, Soares, Claudia
Format: Preprint
Veröffentlicht: 2025
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author Gambetti, Alessandro
Han, Qiwei
Shen, Hong
Soares, Claudia
author_facet Gambetti, Alessandro
Han, Qiwei
Shen, Hong
Soares, Claudia
contents Explainable Artificial Intelligence (XAI) is essential for the transparency and clinical adoption of Clinical Decision Support Systems (CDSS). However, the real-world effectiveness of existing XAI methods remains limited and is inconsistently evaluated. This study conducts a systematic PRISMA-guided survey of 31 human-centered evaluations (HCE) of XAI applied to CDSS, classifying them by XAI methodology, evaluation design, and adoption barrier. Our findings reveal that most existing studies employ post-hoc, model-agnostic approaches such as SHAP and Grad-CAM, typically assessed through small-scale clinician studies. The results show that over 80% of the studies adopt post-hoc, model-agnostic approaches such as SHAP and Grad-CAM, and that clinician sample sizes remain below 25 participants. The findings indicate that explanations generally improve clinician trust and diagnostic confidence, but frequently increase cognitive load and exhibit misalignment with domain reasoning processes. To bridge these gaps, we propose a stakeholder-centric evaluation framework that integrates socio-technical principles and human-computer interaction to guide the future development of clinically viable and trustworthy XAI-based CDSS.
format Preprint
id arxiv_https___arxiv_org_abs_2502_09849
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle A Survey on Human-Centered Evaluation of Explainable AI Methods in Clinical Decision Support Systems
Gambetti, Alessandro
Han, Qiwei
Shen, Hong
Soares, Claudia
Machine Learning
Human-Computer Interaction
Explainable Artificial Intelligence (XAI) is essential for the transparency and clinical adoption of Clinical Decision Support Systems (CDSS). However, the real-world effectiveness of existing XAI methods remains limited and is inconsistently evaluated. This study conducts a systematic PRISMA-guided survey of 31 human-centered evaluations (HCE) of XAI applied to CDSS, classifying them by XAI methodology, evaluation design, and adoption barrier. Our findings reveal that most existing studies employ post-hoc, model-agnostic approaches such as SHAP and Grad-CAM, typically assessed through small-scale clinician studies. The results show that over 80% of the studies adopt post-hoc, model-agnostic approaches such as SHAP and Grad-CAM, and that clinician sample sizes remain below 25 participants. The findings indicate that explanations generally improve clinician trust and diagnostic confidence, but frequently increase cognitive load and exhibit misalignment with domain reasoning processes. To bridge these gaps, we propose a stakeholder-centric evaluation framework that integrates socio-technical principles and human-computer interaction to guide the future development of clinically viable and trustworthy XAI-based CDSS.
title A Survey on Human-Centered Evaluation of Explainable AI Methods in Clinical Decision Support Systems
topic Machine Learning
Human-Computer Interaction
url https://arxiv.org/abs/2502.09849