Offset geometry for extended field-of-view in multi-contrast and multi-scale X-ray microtomography of lung cancer lobectomy specimens
Fuente:
arXiv
Salvato in:
| Autori principali: | , , , , , , , , , , , , , , , |
|---|---|
| Natura: | Preprint |
| Pubblicazione: |
2025
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1866915152552525824 |
|---|---|
| author | Allan, Harry Doherty, Adam Navarrete-León, Carlos Morgó, Oriol Roche i Jia, Yunpeng Percival, Charlotte Hagel, Zoe Otter, Kate E J Khaw, Chuen Ryan Gowers, Kate Hall, Helen Janes, Sam M Monk, Fleur Moore, David Jacob, Joseph Endrizzi, Marco |
| author_facet | Allan, Harry Doherty, Adam Navarrete-León, Carlos Morgó, Oriol Roche i Jia, Yunpeng Percival, Charlotte Hagel, Zoe Otter, Kate E J Khaw, Chuen Ryan Gowers, Kate Hall, Helen Janes, Sam M Monk, Fleur Moore, David Jacob, Joseph Endrizzi, Marco |
| contents | X-ray microtomography is a powerful non-destructive technique allowing 3D virtual histology of resected human tissue. The achievable imaging field-of-view, is however limited by the fixed number of detector elements, enforcing the requirement to sacrifice spatial resolution in order to image larger samples. In applications such as soft-tissue imaging, phase-contrast methods are often employed to enhance image contrast. Some of these methods, especially those suited to laboratory sources, rely on optical elements, the dimensions of which can impose a further limitation on the field-of-view. We describe an efficient method to double the maximum field-of-view of a cone-beam X-ray microtomography system, without sacrificing on spatial resolution, and including multi-contrast capabilities. We demonstrate an experimental realisation of the method, achieving exemplary reconstructions of a resected human lung sample, with a cubic voxel of 10.5 $μ$m linear dimensions, across a horizontal field-of-view of 4.3 cm. The same concepts are applied to free-space propagation imaging of a 2.7 mm segment of the same sample, achieving a cubic voxel of 450 nm linear dimensions. We show that the methodology can be applied at a range of different length-scales and geometries, and that it is directly compatible with complementary implementations of X-ray phase-contrast imaging. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_10322 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Offset geometry for extended field-of-view in multi-contrast and multi-scale X-ray microtomography of lung cancer lobectomy specimens Allan, Harry Doherty, Adam Navarrete-León, Carlos Morgó, Oriol Roche i Jia, Yunpeng Percival, Charlotte Hagel, Zoe Otter, Kate E J Khaw, Chuen Ryan Gowers, Kate Hall, Helen Janes, Sam M Monk, Fleur Moore, David Jacob, Joseph Endrizzi, Marco Medical Physics Instrumentation and Detectors X-ray microtomography is a powerful non-destructive technique allowing 3D virtual histology of resected human tissue. The achievable imaging field-of-view, is however limited by the fixed number of detector elements, enforcing the requirement to sacrifice spatial resolution in order to image larger samples. In applications such as soft-tissue imaging, phase-contrast methods are often employed to enhance image contrast. Some of these methods, especially those suited to laboratory sources, rely on optical elements, the dimensions of which can impose a further limitation on the field-of-view. We describe an efficient method to double the maximum field-of-view of a cone-beam X-ray microtomography system, without sacrificing on spatial resolution, and including multi-contrast capabilities. We demonstrate an experimental realisation of the method, achieving exemplary reconstructions of a resected human lung sample, with a cubic voxel of 10.5 $μ$m linear dimensions, across a horizontal field-of-view of 4.3 cm. The same concepts are applied to free-space propagation imaging of a 2.7 mm segment of the same sample, achieving a cubic voxel of 450 nm linear dimensions. We show that the methodology can be applied at a range of different length-scales and geometries, and that it is directly compatible with complementary implementations of X-ray phase-contrast imaging. |
| title | Offset geometry for extended field-of-view in multi-contrast and multi-scale X-ray microtomography of lung cancer lobectomy specimens |
| topic | Medical Physics Instrumentation and Detectors |
| url | https://arxiv.org/abs/2502.10322 |