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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2502.10322 |
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Table of Contents:
- X-ray microtomography is a powerful non-destructive technique allowing 3D virtual histology of resected human tissue. The achievable imaging field-of-view, is however limited by the fixed number of detector elements, enforcing the requirement to sacrifice spatial resolution in order to image larger samples. In applications such as soft-tissue imaging, phase-contrast methods are often employed to enhance image contrast. Some of these methods, especially those suited to laboratory sources, rely on optical elements, the dimensions of which can impose a further limitation on the field-of-view. We describe an efficient method to double the maximum field-of-view of a cone-beam X-ray microtomography system, without sacrificing on spatial resolution, and including multi-contrast capabilities. We demonstrate an experimental realisation of the method, achieving exemplary reconstructions of a resected human lung sample, with a cubic voxel of 10.5 $μ$m linear dimensions, across a horizontal field-of-view of 4.3 cm. The same concepts are applied to free-space propagation imaging of a 2.7 mm segment of the same sample, achieving a cubic voxel of 450 nm linear dimensions. We show that the methodology can be applied at a range of different length-scales and geometries, and that it is directly compatible with complementary implementations of X-ray phase-contrast imaging.