Incomplete Modality Disentangled Representation for Ophthalmic Disease Grading and Diagnosis

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Hauptverfasser: Liu, Chengzhi, Huang, Zile, Chen, Zhe, Tang, Feilong, Tian, Yu, Xu, Zhongxing, Luo, Zihong, Zheng, Yalin, Meng, Yanda
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Veröffentlicht: 2025
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author Liu, Chengzhi
Huang, Zile
Chen, Zhe
Tang, Feilong
Tian, Yu
Xu, Zhongxing
Luo, Zihong
Zheng, Yalin
Meng, Yanda
author_facet Liu, Chengzhi
Huang, Zile
Chen, Zhe
Tang, Feilong
Tian, Yu
Xu, Zhongxing
Luo, Zihong
Zheng, Yalin
Meng, Yanda
contents Ophthalmologists typically require multimodal data sources to improve diagnostic accuracy in clinical decisions. However, due to medical device shortages, low-quality data and data privacy concerns, missing data modalities are common in real-world scenarios. Existing deep learning methods tend to address it by learning an implicit latent subspace representation for different modality combinations. We identify two significant limitations of these methods: (1) implicit representation constraints that hinder the model's ability to capture modality-specific information and (2) modality heterogeneity, causing distribution gaps and redundancy in feature representations. To address these, we propose an Incomplete Modality Disentangled Representation (IMDR) strategy, which disentangles features into explicit independent modal-common and modal-specific features by guidance of mutual information, distilling informative knowledge and enabling it to reconstruct valuable missing semantics and produce robust multimodal representations. Furthermore, we introduce a joint proxy learning module that assists IMDR in eliminating intra-modality redundancy by exploiting the extracted proxies from each class. Experiments on four ophthalmology multimodal datasets demonstrate that the proposed IMDR outperforms the state-of-the-art methods significantly.
format Preprint
id arxiv_https___arxiv_org_abs_2502_11724
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Incomplete Modality Disentangled Representation for Ophthalmic Disease Grading and Diagnosis
Liu, Chengzhi
Huang, Zile
Chen, Zhe
Tang, Feilong
Tian, Yu
Xu, Zhongxing
Luo, Zihong
Zheng, Yalin
Meng, Yanda
Computer Vision and Pattern Recognition
Ophthalmologists typically require multimodal data sources to improve diagnostic accuracy in clinical decisions. However, due to medical device shortages, low-quality data and data privacy concerns, missing data modalities are common in real-world scenarios. Existing deep learning methods tend to address it by learning an implicit latent subspace representation for different modality combinations. We identify two significant limitations of these methods: (1) implicit representation constraints that hinder the model's ability to capture modality-specific information and (2) modality heterogeneity, causing distribution gaps and redundancy in feature representations. To address these, we propose an Incomplete Modality Disentangled Representation (IMDR) strategy, which disentangles features into explicit independent modal-common and modal-specific features by guidance of mutual information, distilling informative knowledge and enabling it to reconstruct valuable missing semantics and produce robust multimodal representations. Furthermore, we introduce a joint proxy learning module that assists IMDR in eliminating intra-modality redundancy by exploiting the extracted proxies from each class. Experiments on four ophthalmology multimodal datasets demonstrate that the proposed IMDR outperforms the state-of-the-art methods significantly.
title Incomplete Modality Disentangled Representation for Ophthalmic Disease Grading and Diagnosis
topic Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2502.11724