Accelerated X-Ray Fluorescence Computed Tomography via Multi-Pencil-Beam Excitation
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arXiv
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866913703013646336 |
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| author | Schmidt, Ryder M. Hara, Daiki Vega, Jorge D. Abuhaija, Marwan Bocian, Brett Ma, Wendi Dogan, Nesrin Pollack, Alan Wang, Ge Ford, John C. Shi, Junwei |
| author_facet | Schmidt, Ryder M. Hara, Daiki Vega, Jorge D. Abuhaija, Marwan Bocian, Brett Ma, Wendi Dogan, Nesrin Pollack, Alan Wang, Ge Ford, John C. Shi, Junwei |
| contents | X-ray fluorescence computed tomography (XFCT), a form of X-ray molecular imaging, offers detailed quantitative imaging capabilities for high-Z metal nanoparticles (MNPs), which are widely studied for their applications in multifunctional theranostics. Due to its affordability and accessibility, the benchtop XFCT prototype typically employs a single-pixel detector (SPD) with single-pencil-beam (SPB) X-ray excitation. While this design (resembling the first-generation CT geometry) achieves reliable detection sensitivity, it is hindered by long imaging times. The use of simultaneous multiple-pencil-beam (MPB) excitation presents a promising solution to significantly reduce imaging times. In this study, we developed a repeatable workflow that combines Monte Carlo (MC) simulations and 3D printing to design Nbeam-MPB collimator, where Nbeam is the number of beams generated by the collimator. As an initial test, we fabricated a 2-MPB collimator and evaluated the performance of 2-MPB-based XFCT imaging on a physical phantom and small animals surgically implanted with agarose pellets containing gold chloride (H[AuCl4]). The results demonstrated a 2x acceleration in image acquisition without compromising the contrast-to-noise ratio (CNR). We further investigated the concept of Nbeam-MPB acceleration on the MC computational XFCT system, which confirmed the feasibility of achieving at least 4x acceleration with 4-MPB excitation. Combined with additional system optimization, such as X-ray beam flux optimization, XFCT imaging could be further accelerated, reducing acquisition time from hours to minutes and meeting the requirements for routine MNP imaging. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_14524 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Accelerated X-Ray Fluorescence Computed Tomography via Multi-Pencil-Beam Excitation Schmidt, Ryder M. Hara, Daiki Vega, Jorge D. Abuhaija, Marwan Bocian, Brett Ma, Wendi Dogan, Nesrin Pollack, Alan Wang, Ge Ford, John C. Shi, Junwei Medical Physics X-ray fluorescence computed tomography (XFCT), a form of X-ray molecular imaging, offers detailed quantitative imaging capabilities for high-Z metal nanoparticles (MNPs), which are widely studied for their applications in multifunctional theranostics. Due to its affordability and accessibility, the benchtop XFCT prototype typically employs a single-pixel detector (SPD) with single-pencil-beam (SPB) X-ray excitation. While this design (resembling the first-generation CT geometry) achieves reliable detection sensitivity, it is hindered by long imaging times. The use of simultaneous multiple-pencil-beam (MPB) excitation presents a promising solution to significantly reduce imaging times. In this study, we developed a repeatable workflow that combines Monte Carlo (MC) simulations and 3D printing to design Nbeam-MPB collimator, where Nbeam is the number of beams generated by the collimator. As an initial test, we fabricated a 2-MPB collimator and evaluated the performance of 2-MPB-based XFCT imaging on a physical phantom and small animals surgically implanted with agarose pellets containing gold chloride (H[AuCl4]). The results demonstrated a 2x acceleration in image acquisition without compromising the contrast-to-noise ratio (CNR). We further investigated the concept of Nbeam-MPB acceleration on the MC computational XFCT system, which confirmed the feasibility of achieving at least 4x acceleration with 4-MPB excitation. Combined with additional system optimization, such as X-ray beam flux optimization, XFCT imaging could be further accelerated, reducing acquisition time from hours to minutes and meeting the requirements for routine MNP imaging. |
| title | Accelerated X-Ray Fluorescence Computed Tomography via Multi-Pencil-Beam Excitation |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2502.14524 |