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| Main Authors: | , , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2502.14534 |
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| _version_ | 1866917930896195584 |
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| author | Xu, Yuchen Peng, Yulong Yao, Yuanfa Fan, Xiaoman Wang, Minmin Gao, Feng Sawan, Mohamad Zhang, Shaomin Hu, Xiaoling |
| author_facet | Xu, Yuchen Peng, Yulong Yao, Yuanfa Fan, Xiaoman Wang, Minmin Gao, Feng Sawan, Mohamad Zhang, Shaomin Hu, Xiaoling |
| contents | Individualized training improved post-stroke motor function rehabilitation efficiency. However, the mechanisms of how individualized training facilitates recovery is not clear. This study explored the cortical and corticomuscular rehabilitative effects in post-stroke motor function recovery during individualized training. Sprague-Dawley rats with intracerebral hemorrhage (ICH) were randomly distributed into two groups: forced training (FOR-T, n=13) and individualized fatigue-controlled training (FAT-C, n=13) to receive training respectively from day 2 to day 14 post-stroke. The FAT-C group exhibited superior motor function recovery and less central fatigue compared to the FOR-T group. EEG PSD slope analysis demonstrated a better inter-hemispheric balance in FAT-C group compare to the FOR-T group. The dCMC analysis indicated that training-induced fatigue led to a short-term down-regulation of descending corticomuscular coherence (dCMC) and an up-regulation of ascending dCMC. In the long term, excessive fatigue hindered the recovery of descending control in the affected hemisphere. The individualized strategy of peripheral fatigue-controlled training achieved better motor function recovery, which could be attributed to the mitigation of central fatigue, optimization of inter-hemispheric balance and enhancement of descending control in the affected hemisphere. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_14534 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Poststroke rehabilitative mechanisms in individualized fatigue level-controlled treadmill training -- a Rat Model Study Xu, Yuchen Peng, Yulong Yao, Yuanfa Fan, Xiaoman Wang, Minmin Gao, Feng Sawan, Mohamad Zhang, Shaomin Hu, Xiaoling Signal Processing Individualized training improved post-stroke motor function rehabilitation efficiency. However, the mechanisms of how individualized training facilitates recovery is not clear. This study explored the cortical and corticomuscular rehabilitative effects in post-stroke motor function recovery during individualized training. Sprague-Dawley rats with intracerebral hemorrhage (ICH) were randomly distributed into two groups: forced training (FOR-T, n=13) and individualized fatigue-controlled training (FAT-C, n=13) to receive training respectively from day 2 to day 14 post-stroke. The FAT-C group exhibited superior motor function recovery and less central fatigue compared to the FOR-T group. EEG PSD slope analysis demonstrated a better inter-hemispheric balance in FAT-C group compare to the FOR-T group. The dCMC analysis indicated that training-induced fatigue led to a short-term down-regulation of descending corticomuscular coherence (dCMC) and an up-regulation of ascending dCMC. In the long term, excessive fatigue hindered the recovery of descending control in the affected hemisphere. The individualized strategy of peripheral fatigue-controlled training achieved better motor function recovery, which could be attributed to the mitigation of central fatigue, optimization of inter-hemispheric balance and enhancement of descending control in the affected hemisphere. |
| title | Poststroke rehabilitative mechanisms in individualized fatigue level-controlled treadmill training -- a Rat Model Study |
| topic | Signal Processing |
| url | https://arxiv.org/abs/2502.14534 |