Turning on the Light: Polymorphism-Induced Photoluminescence in Cysteine Crystals
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arXiv
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2025
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| author | Banerjee, Debarshi Chibh, Sonika Tiwari, Om Shanker Mirón, Gonzalo Díaz Monti, Marta Yakir, Hadar R. Pawar, Shweta Fixler, Dror Shimon, Linda J. W. Gazit, Ehud Hassanali, Ali |
| author_facet | Banerjee, Debarshi Chibh, Sonika Tiwari, Om Shanker Mirón, Gonzalo Díaz Monti, Marta Yakir, Hadar R. Pawar, Shweta Fixler, Dror Shimon, Linda J. W. Gazit, Ehud Hassanali, Ali |
| contents | Photoluminescence of non-aromatic supramolecular chemical assemblies has attracted considerable attention in recent years due to its potential for use in molecular sensing and imaging technologies. The underlying structural origins, the mechanisms of light emission in these systems, and the generality of this phenomenon remain elusive. Here, we demonstrate that crystals of L-Cysteine (Cys) formed in heavy water ($\text{D}_2\text{O}$) exhibit distinct packing and hydrogen-bond networks, resulting in significantly enhanced photoluminescence compared to those prepared in $\text{H}_2\text{O}$. Using advanced excited-state simulations, we elucidate the nature of electronic transitions that activate vibrational modes of Cys in $\text{H}_2\text{O}$, particularly those involving thiol (S-H) and amine (C-N) groups, which lead to non-radiative decay. For the crystal formed in $\text{D}_2\text{O}$, these modes appear to be more constrained, and we also observe intersystem crossing from the singlet to the triplet state, indicating a potentially more complex light emission mechanism. Our findings provide new insights into this intriguing phenomenon and introduce innovative design principles for generating emergent fluorophores. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_14826 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Turning on the Light: Polymorphism-Induced Photoluminescence in Cysteine Crystals Banerjee, Debarshi Chibh, Sonika Tiwari, Om Shanker Mirón, Gonzalo Díaz Monti, Marta Yakir, Hadar R. Pawar, Shweta Fixler, Dror Shimon, Linda J. W. Gazit, Ehud Hassanali, Ali Chemical Physics Biological Physics Optics Photoluminescence of non-aromatic supramolecular chemical assemblies has attracted considerable attention in recent years due to its potential for use in molecular sensing and imaging technologies. The underlying structural origins, the mechanisms of light emission in these systems, and the generality of this phenomenon remain elusive. Here, we demonstrate that crystals of L-Cysteine (Cys) formed in heavy water ($\text{D}_2\text{O}$) exhibit distinct packing and hydrogen-bond networks, resulting in significantly enhanced photoluminescence compared to those prepared in $\text{H}_2\text{O}$. Using advanced excited-state simulations, we elucidate the nature of electronic transitions that activate vibrational modes of Cys in $\text{H}_2\text{O}$, particularly those involving thiol (S-H) and amine (C-N) groups, which lead to non-radiative decay. For the crystal formed in $\text{D}_2\text{O}$, these modes appear to be more constrained, and we also observe intersystem crossing from the singlet to the triplet state, indicating a potentially more complex light emission mechanism. Our findings provide new insights into this intriguing phenomenon and introduce innovative design principles for generating emergent fluorophores. |
| title | Turning on the Light: Polymorphism-Induced Photoluminescence in Cysteine Crystals |
| topic | Chemical Physics Biological Physics Optics |
| url | https://arxiv.org/abs/2502.14826 |