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| Main Authors: | , , , , , |
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| Format: | Preprint |
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2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2502.15645 |
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| _version_ | 1866916624919953408 |
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| author | Ghimire, Suvash Wu, Yi Chug, Manjyot Kaur Brisbois, Elizabeth J. Kim, Kyungtae Mukhopadhyay, Kausik |
| author_facet | Ghimire, Suvash Wu, Yi Chug, Manjyot Kaur Brisbois, Elizabeth J. Kim, Kyungtae Mukhopadhyay, Kausik |
| contents | Microbes and pathogens play a detrimental role in healing wounds, causing infections like impetigo through bodily fluids and skin and entering the bloodstream through the wounds, thereby hindering the healing process and tissue regeneration. Clay, known for its long history of natural therapeutic use, has emerged as one of the most promising candidates for biomedical applications due to its non-toxic nature, porosity, high surface area, ubiquity, and excellent cation exchange capacity. This study demonstrates an innovative approach to engineering an organo-functionalized, infection-resistant, easy-to-use bandage material from clay, an environmentally benign and sustainable material. The hybrid membranes have been developed using clays, zwitterions, silver ions, and terbinafine hydrochloride (TBH) to impart antibacterial and antifungal efficacy. A critical aspect of this study is embedding organic molecules and metal ions with the clays and releasing them to resist the growth and kill the pathogens. The antimicrobial efficacy of the membranes has been tested using a zone of inhibition study against the most common microbes in skin wounds, viz. S. aureus, E. coli, and C. albicans. Results from our studies not only demonstrate the potential of these hybrid clay membranes as a cost-effective, scalable, and effective solution for treating microbial infections but also instill newer avenues for point-of-care wound-healing treatments, offering hope for improved patient outcomes. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_15645 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Engineered Zwitterion-Infused Clay Composites with Antibacterial and Antifungal Efficacy Ghimire, Suvash Wu, Yi Chug, Manjyot Kaur Brisbois, Elizabeth J. Kim, Kyungtae Mukhopadhyay, Kausik Biomolecules Microbes and pathogens play a detrimental role in healing wounds, causing infections like impetigo through bodily fluids and skin and entering the bloodstream through the wounds, thereby hindering the healing process and tissue regeneration. Clay, known for its long history of natural therapeutic use, has emerged as one of the most promising candidates for biomedical applications due to its non-toxic nature, porosity, high surface area, ubiquity, and excellent cation exchange capacity. This study demonstrates an innovative approach to engineering an organo-functionalized, infection-resistant, easy-to-use bandage material from clay, an environmentally benign and sustainable material. The hybrid membranes have been developed using clays, zwitterions, silver ions, and terbinafine hydrochloride (TBH) to impart antibacterial and antifungal efficacy. A critical aspect of this study is embedding organic molecules and metal ions with the clays and releasing them to resist the growth and kill the pathogens. The antimicrobial efficacy of the membranes has been tested using a zone of inhibition study against the most common microbes in skin wounds, viz. S. aureus, E. coli, and C. albicans. Results from our studies not only demonstrate the potential of these hybrid clay membranes as a cost-effective, scalable, and effective solution for treating microbial infections but also instill newer avenues for point-of-care wound-healing treatments, offering hope for improved patient outcomes. |
| title | Engineered Zwitterion-Infused Clay Composites with Antibacterial and Antifungal Efficacy |
| topic | Biomolecules |
| url | https://arxiv.org/abs/2502.15645 |