Predictability of temporal network dynamics in normal ageing and brain pathology
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arXiv
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| Autori principali: | , , , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2025
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| _version_ | 1866917934420459520 |
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| author | Caligiuri, Annalisa Papo, David Yener, Görsev Güntekin, Bahar Galla, Tobias Lacasa, Lucas Zanin, Massimiliano |
| author_facet | Caligiuri, Annalisa Papo, David Yener, Görsev Güntekin, Bahar Galla, Tobias Lacasa, Lucas Zanin, Massimiliano |
| contents | Spontaneous brain activity generically displays transient spatiotemporal coherent structures, which can selectively be affected in various neurological and psychiatric pathologies. Here we model the full brain's electroencephalographic activity as a high-dimensional functional network performing a trajectory in a latent graph phase space. This approach allows us to investigate the orbital stability of brain's activity and in particular its short-term predictability. We do this by constructing a non-parametric statistic quantifying the expansion of initially close functional network trajectories. We apply the method to cohorts of healthy ageing individuals, and patients previously diagnosed with Parkinson's or Alzheimer's disease. Results not only characterise brain dynamics from a new angle, but further show that functional network predictability varies in a marked scale-dependent way across healthy controls and patient groups. The path towards both pathologies is markedly different. Furthermore, healthy ageing's predictability appears to strongly differ from that of Parkinson's disease, but much less from that of patients with Alzheimer's disease. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_16557 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Predictability of temporal network dynamics in normal ageing and brain pathology Caligiuri, Annalisa Papo, David Yener, Görsev Güntekin, Bahar Galla, Tobias Lacasa, Lucas Zanin, Massimiliano Neurons and Cognition Spontaneous brain activity generically displays transient spatiotemporal coherent structures, which can selectively be affected in various neurological and psychiatric pathologies. Here we model the full brain's electroencephalographic activity as a high-dimensional functional network performing a trajectory in a latent graph phase space. This approach allows us to investigate the orbital stability of brain's activity and in particular its short-term predictability. We do this by constructing a non-parametric statistic quantifying the expansion of initially close functional network trajectories. We apply the method to cohorts of healthy ageing individuals, and patients previously diagnosed with Parkinson's or Alzheimer's disease. Results not only characterise brain dynamics from a new angle, but further show that functional network predictability varies in a marked scale-dependent way across healthy controls and patient groups. The path towards both pathologies is markedly different. Furthermore, healthy ageing's predictability appears to strongly differ from that of Parkinson's disease, but much less from that of patients with Alzheimer's disease. |
| title | Predictability of temporal network dynamics in normal ageing and brain pathology |
| topic | Neurons and Cognition |
| url | https://arxiv.org/abs/2502.16557 |