Knowledge-enhanced Multimodal ECG Representation Learning with Arbitrary-Lead Inputs

Fuente: arXiv
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Main Authors: Liu, Che, Ouyang, Cheng, Wan, Zhongwei, Wang, Haozhe, Bai, Wenjia, Arcucci, Rossella
Format: Preprint
Published: 2025
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author Liu, Che
Ouyang, Cheng
Wan, Zhongwei
Wang, Haozhe
Bai, Wenjia
Arcucci, Rossella
author_facet Liu, Che
Ouyang, Cheng
Wan, Zhongwei
Wang, Haozhe
Bai, Wenjia
Arcucci, Rossella
contents Recent advances in multimodal ECG representation learning center on aligning ECG signals with paired free-text reports. However, suboptimal alignment persists due to the complexity of medical language and the reliance on a full 12-lead setup, which is often unavailable in under-resourced settings. To tackle these issues, we propose **K-MERL**, a knowledge-enhanced multimodal ECG representation learning framework. **K-MERL** leverages large language models to extract structured knowledge from free-text reports and employs a lead-aware ECG encoder with dynamic lead masking to accommodate arbitrary lead inputs. Evaluations on six external ECG datasets show that **K-MERL** achieves state-of-the-art performance in zero-shot classification and linear probing tasks, while delivering an average **16%** AUC improvement over existing methods in partial-lead zero-shot classification.
format Preprint
id arxiv_https___arxiv_org_abs_2502_17900
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Knowledge-enhanced Multimodal ECG Representation Learning with Arbitrary-Lead Inputs
Liu, Che
Ouyang, Cheng
Wan, Zhongwei
Wang, Haozhe
Bai, Wenjia
Arcucci, Rossella
Machine Learning
Artificial Intelligence
Recent advances in multimodal ECG representation learning center on aligning ECG signals with paired free-text reports. However, suboptimal alignment persists due to the complexity of medical language and the reliance on a full 12-lead setup, which is often unavailable in under-resourced settings. To tackle these issues, we propose **K-MERL**, a knowledge-enhanced multimodal ECG representation learning framework. **K-MERL** leverages large language models to extract structured knowledge from free-text reports and employs a lead-aware ECG encoder with dynamic lead masking to accommodate arbitrary lead inputs. Evaluations on six external ECG datasets show that **K-MERL** achieves state-of-the-art performance in zero-shot classification and linear probing tasks, while delivering an average **16%** AUC improvement over existing methods in partial-lead zero-shot classification.
title Knowledge-enhanced Multimodal ECG Representation Learning with Arbitrary-Lead Inputs
topic Machine Learning
Artificial Intelligence
url https://arxiv.org/abs/2502.17900