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| Main Authors: | , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2502.21138 |
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| _version_ | 1866908343600152576 |
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| author | Jhee, Jong Ho Megina, Alberto Beaufils, Pacôme Constant Dit Karakachoff, Matilde Redon, Richard Gaignard, Alban Coulet, Adrien |
| author_facet | Jhee, Jong Ho Megina, Alberto Beaufils, Pacôme Constant Dit Karakachoff, Matilde Redon, Richard Gaignard, Alban Coulet, Adrien |
| contents | Background: With the increasing availability of healthcare data, predictive modeling finds many applications in the biomedical domain, such as the evaluation of the level of risk for various conditions, which in turn can guide clinical decision making. However, it is unclear how knowledge graph data representations and their embedding, which are competitive in some settings, could be of interest in biomedical predictive modeling. Method: We simulated synthetic but realistic data of patients with intracranial aneurysm and experimented on the task of predicting their clinical outcome. We compared the performance of various classification approaches on tabular data versus a graph-based representation of the same data. Next, we investigated how the adopted schema for representing first individual data and second temporal data impacts predictive performances. Results: Our study illustrates that in our case, a graph representation and Graph Convolutional Network (GCN) embeddings reach the best performance for a predictive task from observational data. We emphasize the importance of the adopted schema and of the consideration of literal values in the representation of individual data. Our study also moderates the relative impact of various time encoding on GCN performance. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2502_21138 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Predicting clinical outcomes from patient care pathways represented with temporal knowledge graphs Jhee, Jong Ho Megina, Alberto Beaufils, Pacôme Constant Dit Karakachoff, Matilde Redon, Richard Gaignard, Alban Coulet, Adrien Machine Learning Artificial Intelligence Background: With the increasing availability of healthcare data, predictive modeling finds many applications in the biomedical domain, such as the evaluation of the level of risk for various conditions, which in turn can guide clinical decision making. However, it is unclear how knowledge graph data representations and their embedding, which are competitive in some settings, could be of interest in biomedical predictive modeling. Method: We simulated synthetic but realistic data of patients with intracranial aneurysm and experimented on the task of predicting their clinical outcome. We compared the performance of various classification approaches on tabular data versus a graph-based representation of the same data. Next, we investigated how the adopted schema for representing first individual data and second temporal data impacts predictive performances. Results: Our study illustrates that in our case, a graph representation and Graph Convolutional Network (GCN) embeddings reach the best performance for a predictive task from observational data. We emphasize the importance of the adopted schema and of the consideration of literal values in the representation of individual data. Our study also moderates the relative impact of various time encoding on GCN performance. |
| title | Predicting clinical outcomes from patient care pathways represented with temporal knowledge graphs |
| topic | Machine Learning Artificial Intelligence |
| url | https://arxiv.org/abs/2502.21138 |