NeuroSymAD: A Neuro-Symbolic Framework for Interpretable Alzheimer's Disease Diagnosis
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arXiv
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| Autori principali: | , , , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2025
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| _version_ | 1866912255140954112 |
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| author | He, Yexiao Wang, Ziyao Zhang, Yuning Dan, Tingting Chen, Tianlong Wu, Guorong Li, Ang |
| author_facet | He, Yexiao Wang, Ziyao Zhang, Yuning Dan, Tingting Chen, Tianlong Wu, Guorong Li, Ang |
| contents | Alzheimer's disease (AD) diagnosis is complex, requiring the integration of imaging and clinical data for accurate assessment. While deep learning has shown promise in brain MRI analysis, it often functions as a black box, limiting interpretability and lacking mechanisms to effectively integrate critical clinical data such as biomarkers, medical history, and demographic information. To bridge this gap, we propose NeuroSymAD, a neuro-symbolic framework that synergizes neural networks with symbolic reasoning. A neural network percepts brain MRI scans, while a large language model (LLM) distills medical rules to guide a symbolic system in reasoning over biomarkers and medical history. This structured integration enhances both diagnostic accuracy and explainability. Experiments on the ADNI dataset demonstrate that NeuroSymAD outperforms state-of-the-art methods by up to 2.91% in accuracy and 3.43% in F1-score while providing transparent and interpretable diagnosis. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2503_00510 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | NeuroSymAD: A Neuro-Symbolic Framework for Interpretable Alzheimer's Disease Diagnosis He, Yexiao Wang, Ziyao Zhang, Yuning Dan, Tingting Chen, Tianlong Wu, Guorong Li, Ang Image and Video Processing Computer Vision and Pattern Recognition Alzheimer's disease (AD) diagnosis is complex, requiring the integration of imaging and clinical data for accurate assessment. While deep learning has shown promise in brain MRI analysis, it often functions as a black box, limiting interpretability and lacking mechanisms to effectively integrate critical clinical data such as biomarkers, medical history, and demographic information. To bridge this gap, we propose NeuroSymAD, a neuro-symbolic framework that synergizes neural networks with symbolic reasoning. A neural network percepts brain MRI scans, while a large language model (LLM) distills medical rules to guide a symbolic system in reasoning over biomarkers and medical history. This structured integration enhances both diagnostic accuracy and explainability. Experiments on the ADNI dataset demonstrate that NeuroSymAD outperforms state-of-the-art methods by up to 2.91% in accuracy and 3.43% in F1-score while providing transparent and interpretable diagnosis. |
| title | NeuroSymAD: A Neuro-Symbolic Framework for Interpretable Alzheimer's Disease Diagnosis |
| topic | Image and Video Processing Computer Vision and Pattern Recognition |
| url | https://arxiv.org/abs/2503.00510 |