Chemically resolved nuclear magnetic resonance spectroscopy by longitudinal magnetization detection with a diamond magnetometer
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arXiv
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| Format: | Preprint |
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2025
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| _version_ | 1866929740373295104 |
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| author | Smits, Janis Silani, Yaser Peng, Zaili Richards, Bryan A. McDowell, Andrew F. Damron, Joshua T. Aiello, Maxwell D. Ziabari, Maziar Saleh Jarmola, Andrey Acosta, Victor M. |
| author_facet | Smits, Janis Silani, Yaser Peng, Zaili Richards, Bryan A. McDowell, Andrew F. Damron, Joshua T. Aiello, Maxwell D. Ziabari, Maziar Saleh Jarmola, Andrey Acosta, Victor M. |
| contents | Non-inductive magnetometers based on solid-state spins offer a promising solution for small-volume nuclear magnetic resonance (NMR) detection. A remaining challenge is to operate at a sufficiently high magnetic field to resolve chemical shifts at the part-per-billion level. Here, we demonstrate a Ramsey-M_z protocol that uses Ramsey interferometry to convert an analyte's transverse spin precession into a longitudinal magnetization (M_z), which is subsequently modulated and detected with a diamond magnetometer. We record NMR spectra at B0=0.32 T with a fractional spectral resolution of ~350 ppb, limited by the stability of the electromagnet bias field. We perform NMR spectroscopy on a ~1 nL detection volume of ethanol and resolve the chemical shift structure with negligible distortion. Through simulation, we show that the protocol can be extended to fields up to B0=3 T, with minimal spectral distortion, using composite nuclear-spin inversion pulses. For sub-nanoliter analyte volumes, we estimate a resolution of ~1 ppb and concentration sensitivity of ~40 mM s^{1/2} is feasible with improvements to the sensor design. Our results establish diamond magnetometers as high-resolution NMR detectors in the moderate magnetic field regime, with potential applications in metabolomics and pharmaceutical research. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2503_02140 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Chemically resolved nuclear magnetic resonance spectroscopy by longitudinal magnetization detection with a diamond magnetometer Smits, Janis Silani, Yaser Peng, Zaili Richards, Bryan A. McDowell, Andrew F. Damron, Joshua T. Aiello, Maxwell D. Ziabari, Maziar Saleh Jarmola, Andrey Acosta, Victor M. Instrumentation and Detectors Applied Physics Chemical Physics Optics Quantum Physics Non-inductive magnetometers based on solid-state spins offer a promising solution for small-volume nuclear magnetic resonance (NMR) detection. A remaining challenge is to operate at a sufficiently high magnetic field to resolve chemical shifts at the part-per-billion level. Here, we demonstrate a Ramsey-M_z protocol that uses Ramsey interferometry to convert an analyte's transverse spin precession into a longitudinal magnetization (M_z), which is subsequently modulated and detected with a diamond magnetometer. We record NMR spectra at B0=0.32 T with a fractional spectral resolution of ~350 ppb, limited by the stability of the electromagnet bias field. We perform NMR spectroscopy on a ~1 nL detection volume of ethanol and resolve the chemical shift structure with negligible distortion. Through simulation, we show that the protocol can be extended to fields up to B0=3 T, with minimal spectral distortion, using composite nuclear-spin inversion pulses. For sub-nanoliter analyte volumes, we estimate a resolution of ~1 ppb and concentration sensitivity of ~40 mM s^{1/2} is feasible with improvements to the sensor design. Our results establish diamond magnetometers as high-resolution NMR detectors in the moderate magnetic field regime, with potential applications in metabolomics and pharmaceutical research. |
| title | Chemically resolved nuclear magnetic resonance spectroscopy by longitudinal magnetization detection with a diamond magnetometer |
| topic | Instrumentation and Detectors Applied Physics Chemical Physics Optics Quantum Physics |
| url | https://arxiv.org/abs/2503.02140 |