FMASH: Advancing Traditional Chinese Medicine Formula Recommendation with Efficient Fusion of Multiscale Associations of Symptoms and Herbs

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Hauptverfasser: Zheng, Xinhan, Wang, Xueting, Li, Ruotai, Wu, Huyu, Jin, Haopeng, Yang, Yehan, Shan, Guodong
Format: Preprint
Veröffentlicht: 2025
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author Zheng, Xinhan
Wang, Xueting
Li, Ruotai
Wu, Huyu
Jin, Haopeng
Yang, Yehan
Shan, Guodong
author_facet Zheng, Xinhan
Wang, Xueting
Li, Ruotai
Wu, Huyu
Jin, Haopeng
Yang, Yehan
Shan, Guodong
contents Traditional Chinese medicine (TCM) exhibits remarkable therapeutic efficacy in healthcare through patient-specific formulas. However, current AI-based TCM formula recommendation models and methods mainly focus on data-based textual associations between symptoms and herbs, and have not fully utilized their features and relations at different scales, especially at the molecular scale. To address these limitations, we propose the Fusion of Multiscale Associations of Symptoms and Herbs (FMASH), a novel framework that effectively incorporates the properties of herbs on different scales with clinical symptoms and provides refined embeddings of their multiscale associations. The framework integrates molecular-scale features and macroscopic properties of herbs and combines complex local and global relations in the heterogeneous graph of symptoms and herbs. Moreover, it provides effective representation embeddings of the multiscale features and associations of symptoms and herbs in a unified semantic space. Comprehensive experiments have been conducted on FMASH, and the results demonstrate that our FMASH-based model outperforms the state-of-the-art (SOTA) model on both datasets, confirming the effectiveness of FMASH in building the TCM formula recommendation model. In Dataset1, our model has achieved a significant improvement compared to the SOTA model, with increases of 3.38% in Precision@5, 3.89% in Recall@5, and 3.69% in F1-score@5. In Dataset2, Precision@5, Recall@5, and F1-score@5 increase by 2.64%, 1.92%, and 2.23%, respectively. This work facilitates the application of the AI-based TCM formula recommendation and promotes the innovative development of TCM diagnosis and treatment.
format Preprint
id arxiv_https___arxiv_org_abs_2503_05167
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle FMASH: Advancing Traditional Chinese Medicine Formula Recommendation with Efficient Fusion of Multiscale Associations of Symptoms and Herbs
Zheng, Xinhan
Wang, Xueting
Li, Ruotai
Wu, Huyu
Jin, Haopeng
Yang, Yehan
Shan, Guodong
Machine Learning
Traditional Chinese medicine (TCM) exhibits remarkable therapeutic efficacy in healthcare through patient-specific formulas. However, current AI-based TCM formula recommendation models and methods mainly focus on data-based textual associations between symptoms and herbs, and have not fully utilized their features and relations at different scales, especially at the molecular scale. To address these limitations, we propose the Fusion of Multiscale Associations of Symptoms and Herbs (FMASH), a novel framework that effectively incorporates the properties of herbs on different scales with clinical symptoms and provides refined embeddings of their multiscale associations. The framework integrates molecular-scale features and macroscopic properties of herbs and combines complex local and global relations in the heterogeneous graph of symptoms and herbs. Moreover, it provides effective representation embeddings of the multiscale features and associations of symptoms and herbs in a unified semantic space. Comprehensive experiments have been conducted on FMASH, and the results demonstrate that our FMASH-based model outperforms the state-of-the-art (SOTA) model on both datasets, confirming the effectiveness of FMASH in building the TCM formula recommendation model. In Dataset1, our model has achieved a significant improvement compared to the SOTA model, with increases of 3.38% in Precision@5, 3.89% in Recall@5, and 3.69% in F1-score@5. In Dataset2, Precision@5, Recall@5, and F1-score@5 increase by 2.64%, 1.92%, and 2.23%, respectively. This work facilitates the application of the AI-based TCM formula recommendation and promotes the innovative development of TCM diagnosis and treatment.
title FMASH: Advancing Traditional Chinese Medicine Formula Recommendation with Efficient Fusion of Multiscale Associations of Symptoms and Herbs
topic Machine Learning
url https://arxiv.org/abs/2503.05167