Compact Accelerator-Based Production of Carrier-free $^{177}$Lu From 18 MeV $D^+$ on [$^{176}$Yb]Yb$_2$O$_3$
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arXiv
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| Autores principales: | , , , , , |
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| Formato: | Preprint |
| Publicado: |
2025
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| _version_ | 1866915186339741696 |
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| author | Morris, Austin A. Wei, Tianhao Wang, Zhi Xia, Ying Han, Meiyun Lu, Yuanrong |
| author_facet | Morris, Austin A. Wei, Tianhao Wang, Zhi Xia, Ying Han, Meiyun Lu, Yuanrong |
| contents | We use experimental and simulated excitation functions to estimate the yield of deuteron activations on a [$^{176}$Yb]Yb$_2$O$_3$ target enriched to 99%. Subsequent calculations are used to determine the production of radiotherapeutic $^{177}$Lu according to a 10 mA, 18 MeV $D^+$ compact linear accelerator. The design comprises a single radio-frequency quadrupole accelerator (RFQ) and seven drift tube linacs (DTLs) that achieve a beam efficiency of 99.5% over a length of $12\,\text{m}$. Our results show that a 5-day irradiation can yield more than $1$ mg of $^{177}$Lu, exceeding $4.4$ TBq. After a 2 day processing period, it is estimated that the sample will have a radiopurity greater than 99.8% (carrier-free). Given recent EMA and FDA approvals of $^{177}$Lu-DOTATATE and $^{177}$Lu-PSMA-617, our results confirm the viability of accelerator-based $^{177}$Lu production and provide a promising clinical alternative to reactor-based methods. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2503_05608 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Compact Accelerator-Based Production of Carrier-free $^{177}$Lu From 18 MeV $D^+$ on [$^{176}$Yb]Yb$_2$O$_3$ Morris, Austin A. Wei, Tianhao Wang, Zhi Xia, Ying Han, Meiyun Lu, Yuanrong Accelerator Physics Medical Physics We use experimental and simulated excitation functions to estimate the yield of deuteron activations on a [$^{176}$Yb]Yb$_2$O$_3$ target enriched to 99%. Subsequent calculations are used to determine the production of radiotherapeutic $^{177}$Lu according to a 10 mA, 18 MeV $D^+$ compact linear accelerator. The design comprises a single radio-frequency quadrupole accelerator (RFQ) and seven drift tube linacs (DTLs) that achieve a beam efficiency of 99.5% over a length of $12\,\text{m}$. Our results show that a 5-day irradiation can yield more than $1$ mg of $^{177}$Lu, exceeding $4.4$ TBq. After a 2 day processing period, it is estimated that the sample will have a radiopurity greater than 99.8% (carrier-free). Given recent EMA and FDA approvals of $^{177}$Lu-DOTATATE and $^{177}$Lu-PSMA-617, our results confirm the viability of accelerator-based $^{177}$Lu production and provide a promising clinical alternative to reactor-based methods. |
| title | Compact Accelerator-Based Production of Carrier-free $^{177}$Lu From 18 MeV $D^+$ on [$^{176}$Yb]Yb$_2$O$_3$ |
| topic | Accelerator Physics Medical Physics |
| url | https://arxiv.org/abs/2503.05608 |