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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2503.05608 |
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Table of Contents:
- We use experimental and simulated excitation functions to estimate the yield of deuteron activations on a [$^{176}$Yb]Yb$_2$O$_3$ target enriched to 99%. Subsequent calculations are used to determine the production of radiotherapeutic $^{177}$Lu according to a 10 mA, 18 MeV $D^+$ compact linear accelerator. The design comprises a single radio-frequency quadrupole accelerator (RFQ) and seven drift tube linacs (DTLs) that achieve a beam efficiency of 99.5% over a length of $12\,\text{m}$. Our results show that a 5-day irradiation can yield more than $1$ mg of $^{177}$Lu, exceeding $4.4$ TBq. After a 2 day processing period, it is estimated that the sample will have a radiopurity greater than 99.8% (carrier-free). Given recent EMA and FDA approvals of $^{177}$Lu-DOTATATE and $^{177}$Lu-PSMA-617, our results confirm the viability of accelerator-based $^{177}$Lu production and provide a promising clinical alternative to reactor-based methods.