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Main Authors: Xu, Teng, Zhou, Taotao, Wang, Youjia, Yang, Peng, Tang, Simin, Shao, Kuixiang, Tang, Zifeng, Liu, Yifei, Chen, Xinyuan, Wang, Hongshuang, Wang, Xiaohui, Luo, Huoqing, Wang, Jingya, Hu, Ji, Yu, Jingyi
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2503.10212
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author Xu, Teng
Zhou, Taotao
Wang, Youjia
Yang, Peng
Tang, Simin
Shao, Kuixiang
Tang, Zifeng
Liu, Yifei
Chen, Xinyuan
Wang, Hongshuang
Wang, Xiaohui
Luo, Huoqing
Wang, Jingya
Hu, Ji
Yu, Jingyi
author_facet Xu, Teng
Zhou, Taotao
Wang, Youjia
Yang, Peng
Tang, Simin
Shao, Kuixiang
Tang, Zifeng
Liu, Yifei
Chen, Xinyuan
Wang, Hongshuang
Wang, Xiaohui
Luo, Huoqing
Wang, Jingya
Hu, Ji
Yu, Jingyi
contents Analyzing animal behavior is crucial in advancing neuroscience, yet quantifying and deciphering its intricate dynamics remains a significant challenge. Traditional machine vision approaches, despite their ability to detect spontaneous behaviors, fall short due to limited interpretability and reliance on manual labeling, which restricts the exploration of the full behavioral spectrum. Here, we introduce MouseGPT, a Vision-Language Model (VLM) that integrates visual cues with natural language to revolutionize mouse behavior analysis. Built upon our first-of-its-kind dataset - incorporating pose dynamics and open-vocabulary behavioral annotations across over 42 million frames of diverse psychiatric conditions - MouseGPT provides a novel, context-rich method for comprehensive behavior interpretation. Our holistic analysis framework enables detailed behavior profiling, clustering, and novel behavior discovery, offering deep insights without the need for labor - intensive manual annotation. Evaluations reveal that MouseGPT surpasses existing models in precision, adaptability, and descriptive richness, positioning it as a transformative tool for ethology and for unraveling complex behavioral dynamics in animal models.
format Preprint
id arxiv_https___arxiv_org_abs_2503_10212
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle MouseGPT: A Large-scale Vision-Language Model for Mouse Behavior Analysis
Xu, Teng
Zhou, Taotao
Wang, Youjia
Yang, Peng
Tang, Simin
Shao, Kuixiang
Tang, Zifeng
Liu, Yifei
Chen, Xinyuan
Wang, Hongshuang
Wang, Xiaohui
Luo, Huoqing
Wang, Jingya
Hu, Ji
Yu, Jingyi
Computer Vision and Pattern Recognition
Analyzing animal behavior is crucial in advancing neuroscience, yet quantifying and deciphering its intricate dynamics remains a significant challenge. Traditional machine vision approaches, despite their ability to detect spontaneous behaviors, fall short due to limited interpretability and reliance on manual labeling, which restricts the exploration of the full behavioral spectrum. Here, we introduce MouseGPT, a Vision-Language Model (VLM) that integrates visual cues with natural language to revolutionize mouse behavior analysis. Built upon our first-of-its-kind dataset - incorporating pose dynamics and open-vocabulary behavioral annotations across over 42 million frames of diverse psychiatric conditions - MouseGPT provides a novel, context-rich method for comprehensive behavior interpretation. Our holistic analysis framework enables detailed behavior profiling, clustering, and novel behavior discovery, offering deep insights without the need for labor - intensive manual annotation. Evaluations reveal that MouseGPT surpasses existing models in precision, adaptability, and descriptive richness, positioning it as a transformative tool for ethology and for unraveling complex behavioral dynamics in animal models.
title MouseGPT: A Large-scale Vision-Language Model for Mouse Behavior Analysis
topic Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2503.10212