Cracking the PUMA Challenge in 24 Hours with CellViT++ and nnU-Net

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Main Authors: Shahamiri, Negar, Rempe, Moritz, Heine, Lukas, Kleesiek, Jens, Hörst, Fabian
Format: Preprint
Published: 2025
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author Shahamiri, Negar
Rempe, Moritz
Heine, Lukas
Kleesiek, Jens
Hörst, Fabian
author_facet Shahamiri, Negar
Rempe, Moritz
Heine, Lukas
Kleesiek, Jens
Hörst, Fabian
contents Automatic tissue segmentation and nuclei detection is an important task in pathology, aiding in biomarker extraction and discovery. The panoptic segmentation of nuclei and tissue in advanced melanoma (PUMA) challenge aims to improve tissue segmentation and nuclei detection in melanoma histopathology. Unlike many challenge submissions focusing on extensive model tuning, our approach emphasizes delivering a deployable solution within a 24-hour development timeframe, using out-of-the-box frameworks. The pipeline combines two models, namely CellViT++ for nuclei detection and nnU-Net for tissue segmentation. Our results demonstrate a significant improvement in tissue segmentation, achieving a Dice score of 0.750, surpassing the baseline score of 0.629. For nuclei detection, we obtained results comparable to the baseline in both challenge tracks. The code is publicly available at https://github.com/TIO-IKIM/PUMA.
format Preprint
id arxiv_https___arxiv_org_abs_2503_12269
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Cracking the PUMA Challenge in 24 Hours with CellViT++ and nnU-Net
Shahamiri, Negar
Rempe, Moritz
Heine, Lukas
Kleesiek, Jens
Hörst, Fabian
Computer Vision and Pattern Recognition
Automatic tissue segmentation and nuclei detection is an important task in pathology, aiding in biomarker extraction and discovery. The panoptic segmentation of nuclei and tissue in advanced melanoma (PUMA) challenge aims to improve tissue segmentation and nuclei detection in melanoma histopathology. Unlike many challenge submissions focusing on extensive model tuning, our approach emphasizes delivering a deployable solution within a 24-hour development timeframe, using out-of-the-box frameworks. The pipeline combines two models, namely CellViT++ for nuclei detection and nnU-Net for tissue segmentation. Our results demonstrate a significant improvement in tissue segmentation, achieving a Dice score of 0.750, surpassing the baseline score of 0.629. For nuclei detection, we obtained results comparable to the baseline in both challenge tracks. The code is publicly available at https://github.com/TIO-IKIM/PUMA.
title Cracking the PUMA Challenge in 24 Hours with CellViT++ and nnU-Net
topic Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2503.12269