Dynamic-OCT simulation framework based on mathematical models of intratissue dynamics, image formation, and measurement noise
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arXiv
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Preprint |
| Publié: |
2025
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| _version_ | 1866911228676276224 |
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| author | Feng, Yuanke Fujimura, Shumpei Lim, Yiheng Seesan, Thitiya Morishita, Rion El-Sadek, Ibrahim Abd Mukherjee, Pradipta Makita, Shuichi Yasuno, Yoshiaki |
| author_facet | Feng, Yuanke Fujimura, Shumpei Lim, Yiheng Seesan, Thitiya Morishita, Rion El-Sadek, Ibrahim Abd Mukherjee, Pradipta Makita, Shuichi Yasuno, Yoshiaki |
| contents | Dynamic optical coherence tomography (DOCT) enables label-free functional imaging by capturing temporal OCT signal variations caused by intracellular and intratissue motions. However, the relationship between DOCT signals and the sample motion behind them remains unclear. This paper presents a comprehensive DOCT simulation framework that incorporates mathematical models of intracellular/intratissue motions, two OCT signal generator types that generate OCT signal time sequences from the moving scatterer models, and representative DOCT algorithms. The theory and algorithms of the framework are described in detail, and the utility of this framework is demonstrated through numerical studies. This framework is available as open source and will enhance the understanding and utility of DOCT. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2503_20407 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Dynamic-OCT simulation framework based on mathematical models of intratissue dynamics, image formation, and measurement noise Feng, Yuanke Fujimura, Shumpei Lim, Yiheng Seesan, Thitiya Morishita, Rion El-Sadek, Ibrahim Abd Mukherjee, Pradipta Makita, Shuichi Yasuno, Yoshiaki Medical Physics Optics Dynamic optical coherence tomography (DOCT) enables label-free functional imaging by capturing temporal OCT signal variations caused by intracellular and intratissue motions. However, the relationship between DOCT signals and the sample motion behind them remains unclear. This paper presents a comprehensive DOCT simulation framework that incorporates mathematical models of intracellular/intratissue motions, two OCT signal generator types that generate OCT signal time sequences from the moving scatterer models, and representative DOCT algorithms. The theory and algorithms of the framework are described in detail, and the utility of this framework is demonstrated through numerical studies. This framework is available as open source and will enhance the understanding and utility of DOCT. |
| title | Dynamic-OCT simulation framework based on mathematical models of intratissue dynamics, image formation, and measurement noise |
| topic | Medical Physics Optics |
| url | https://arxiv.org/abs/2503.20407 |