Intermittent flow paths in biofilms grown in a microfluidic channel
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arXiv
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| Main Authors: | , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866912302187413504 |
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| author | Bozkurt, Kerem Lohrmann, Christoph Weinhardt, Felix Hanke, Daniel Hopp, Raphael Gerlach, Robin Holm, Christian Class, Holger |
| author_facet | Bozkurt, Kerem Lohrmann, Christoph Weinhardt, Felix Hanke, Daniel Hopp, Raphael Gerlach, Robin Holm, Christian Class, Holger |
| contents | Biofilms exposed to flow experience shear stress, which leads to a competitive interaction between the growth and development of a biofilm and shearing. In this study, Pseudonomas fluorescene biofilm was grown in a microfluidic channel and exposed to forced flow of an aqueous solution of variable velocity. It can be observed that under certain conditions preferential flow paths form with a dynamic, but quasi-steady state interaction of growth, detachment, and re-attachment. We find that the regimes for preferential flow path development are determined by nutrient availability and the ratio of shear stress versus the biofilm's ability to resist shear forces. The intermittent regime of flow paths is mainly driven by the supply with nutrients, which we confirm by comparison with a numerical model based on coarse-grained molecular dynamics and Lattice Boltzmann hydrodynamics. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2504_00062 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Intermittent flow paths in biofilms grown in a microfluidic channel Bozkurt, Kerem Lohrmann, Christoph Weinhardt, Felix Hanke, Daniel Hopp, Raphael Gerlach, Robin Holm, Christian Class, Holger Fluid Dynamics Biological Physics Biofilms exposed to flow experience shear stress, which leads to a competitive interaction between the growth and development of a biofilm and shearing. In this study, Pseudonomas fluorescene biofilm was grown in a microfluidic channel and exposed to forced flow of an aqueous solution of variable velocity. It can be observed that under certain conditions preferential flow paths form with a dynamic, but quasi-steady state interaction of growth, detachment, and re-attachment. We find that the regimes for preferential flow path development are determined by nutrient availability and the ratio of shear stress versus the biofilm's ability to resist shear forces. The intermittent regime of flow paths is mainly driven by the supply with nutrients, which we confirm by comparison with a numerical model based on coarse-grained molecular dynamics and Lattice Boltzmann hydrodynamics. |
| title | Intermittent flow paths in biofilms grown in a microfluidic channel |
| topic | Fluid Dynamics Biological Physics |
| url | https://arxiv.org/abs/2504.00062 |