Addressing missing context in regulatory variation across primate evolution
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arXiv
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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866915224787877888 |
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| author | Housman, Genevieve Arner, Audrey Longtin, Amy Gagnon, Christian Durvasula, Arun Lea, Amanda |
| author_facet | Housman, Genevieve Arner, Audrey Longtin, Amy Gagnon, Christian Durvasula, Arun Lea, Amanda |
| contents | In primates, loci associated with adaptive trait variation often fall in non-coding regions. Understanding the mechanisms linking these regulatory variants to fitness-relevant phenotypes remains challenging, but can be addressed using functional genomic data. However, such data are rarely generated at scale in non-human primates. When they are, only select tissues, cell types, developmental stages, and cellular environments are typically considered, despite appreciation that adaptive variants often exhibit context-dependent effects. In this review, we 1) discuss why context-dependent regulatory loci might be especially evolutionarily relevant in primates, 2) explore challenges and emerging solutions for mapping such context-dependent variation, and 3) discuss the scientific questions these data could address. We argue that filling this gap will provide critical insights into evolutionary processes, human disease, and regulatory adaptation. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2504_02081 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Addressing missing context in regulatory variation across primate evolution Housman, Genevieve Arner, Audrey Longtin, Amy Gagnon, Christian Durvasula, Arun Lea, Amanda Genomics Populations and Evolution In primates, loci associated with adaptive trait variation often fall in non-coding regions. Understanding the mechanisms linking these regulatory variants to fitness-relevant phenotypes remains challenging, but can be addressed using functional genomic data. However, such data are rarely generated at scale in non-human primates. When they are, only select tissues, cell types, developmental stages, and cellular environments are typically considered, despite appreciation that adaptive variants often exhibit context-dependent effects. In this review, we 1) discuss why context-dependent regulatory loci might be especially evolutionarily relevant in primates, 2) explore challenges and emerging solutions for mapping such context-dependent variation, and 3) discuss the scientific questions these data could address. We argue that filling this gap will provide critical insights into evolutionary processes, human disease, and regulatory adaptation. |
| title | Addressing missing context in regulatory variation across primate evolution |
| topic | Genomics Populations and Evolution |
| url | https://arxiv.org/abs/2504.02081 |