A complimentary impedance spectroscopy biosensing method with graphene
Fuente:
arXiv
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Preprint |
| Veröffentlicht: |
2025
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1866916672939491328 |
|---|---|
| author | Khan, Munis Mijakovic, Ivan Pandit, Santosh Yurgens, August |
| author_facet | Khan, Munis Mijakovic, Ivan Pandit, Santosh Yurgens, August |
| contents | We present a method where a bioactive functional layer on an electrically conductive thin film with high sheet resistance can be effectively used for complementary electrochemical impedance spectroscopy biosensing. The functional layer's properties, such as double-layer capacitance and charge-transfer resistance, influence the complex impedance of the thin film in direct contact with the layer. These measurements can be performed using a simple low-frequency setup with a lock-in amplifier. When graphene is used as the resistive thin film, the signal may also include contributions from graphene's quantum capacitance, which is sensitive to charge transfer to and from the graphene. Unlike in traditional graphene biosensors, changes in electrolyte properties over time, such as those caused by the dissolution of ambient gases, do not significantly affect AC measurements. This technique supports biosensor miniaturization, ensures stable operation, and provides reliable biomarker detection with a high signal-to-noise ratio. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2504_02510 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | A complimentary impedance spectroscopy biosensing method with graphene Khan, Munis Mijakovic, Ivan Pandit, Santosh Yurgens, August Materials Science Applied Physics Biological Physics We present a method where a bioactive functional layer on an electrically conductive thin film with high sheet resistance can be effectively used for complementary electrochemical impedance spectroscopy biosensing. The functional layer's properties, such as double-layer capacitance and charge-transfer resistance, influence the complex impedance of the thin film in direct contact with the layer. These measurements can be performed using a simple low-frequency setup with a lock-in amplifier. When graphene is used as the resistive thin film, the signal may also include contributions from graphene's quantum capacitance, which is sensitive to charge transfer to and from the graphene. Unlike in traditional graphene biosensors, changes in electrolyte properties over time, such as those caused by the dissolution of ambient gases, do not significantly affect AC measurements. This technique supports biosensor miniaturization, ensures stable operation, and provides reliable biomarker detection with a high signal-to-noise ratio. |
| title | A complimentary impedance spectroscopy biosensing method with graphene |
| topic | Materials Science Applied Physics Biological Physics |
| url | https://arxiv.org/abs/2504.02510 |