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| Main Authors: | , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2504.02680 |
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| _version_ | 1866917975805657088 |
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| author | Zorrilla, Luc Allard, Antoine Desai, Krish Polin, Marco |
| author_facet | Zorrilla, Luc Allard, Antoine Desai, Krish Polin, Marco |
| contents | While hydrodynamic coupling has long been considered essential for synchronisation of eukaryotic flagella, recent experiments on the unicellular biflagellate model organism {\it Chlamydomonas} demonstrate that -- at the single cell level -- intracellular mechanical coupling is necessary for coordination. It is therefore unclear what role, if any, hydrodynamic forces actually play in the synchronisation of multiple flagella within individual cells, arguably the building block of large scale coordination. Here we address this question experimentally by transiently blocking hydrodynamic coupling between the two flagella of single {\it Chlamydomonas}. Our results reveal that in wild type cells intracellularly-mediated forces are necessary and sufficient for flagellar synchronisation, with hydrodynamic coupling causing minimal changes in flagellar dynamics. However, fluid-mediated ciliary coupling is responsible for the extended periods of anti-phase synchronisation observed in a mutant with weaker intracellular coupling. At the single-cell level, therefore, flagellar coordination depends on a subtle balance between intracellular and extracellular forces. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2504_02680 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | The role of hydrodynamics in the synchronisation of {\it Chlamydomonas} flagella Zorrilla, Luc Allard, Antoine Desai, Krish Polin, Marco Biological Physics Cell Behavior While hydrodynamic coupling has long been considered essential for synchronisation of eukaryotic flagella, recent experiments on the unicellular biflagellate model organism {\it Chlamydomonas} demonstrate that -- at the single cell level -- intracellular mechanical coupling is necessary for coordination. It is therefore unclear what role, if any, hydrodynamic forces actually play in the synchronisation of multiple flagella within individual cells, arguably the building block of large scale coordination. Here we address this question experimentally by transiently blocking hydrodynamic coupling between the two flagella of single {\it Chlamydomonas}. Our results reveal that in wild type cells intracellularly-mediated forces are necessary and sufficient for flagellar synchronisation, with hydrodynamic coupling causing minimal changes in flagellar dynamics. However, fluid-mediated ciliary coupling is responsible for the extended periods of anti-phase synchronisation observed in a mutant with weaker intracellular coupling. At the single-cell level, therefore, flagellar coordination depends on a subtle balance between intracellular and extracellular forces. |
| title | The role of hydrodynamics in the synchronisation of {\it Chlamydomonas} flagella |
| topic | Biological Physics Cell Behavior |
| url | https://arxiv.org/abs/2504.02680 |