Mathematical Modeling of Soil-Transmitted Helminth Infection: Human-Animal Dynamics with Environmental Reservoirs
Fuente:
arXiv
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | Preprint |
| Publicado: |
2025
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866910903413243904 |
|---|---|
| author | Imoro, Rafiatu Gavina, Maica Krizna Paller, Vachel Gay Rabajante, Jomar Cortez, Mark Jayson Jose, Editha |
| author_facet | Imoro, Rafiatu Gavina, Maica Krizna Paller, Vachel Gay Rabajante, Jomar Cortez, Mark Jayson Jose, Editha |
| contents | Soil-transmitted helminth (STH) infections, one of the most prevalent neglected tropical diseases, pose a significant threat to public health in tropical and subtropical areas. These parasites infect humans and animals through direct contact with contaminated soil or accidental ingestion. This study examines the dynamics of STH transmission using a deterministic compartmental model and nonlinear ordinary differential equations. Our model incorporates the roles humans, animals, and the environment play as reservoirs for spreading STH. We derived the basic reproduction number and demonstrate that the disease-free and endemic equilibrium points are asymptotically stable under specific thresholds. We also performed a sensitivity analysis to determine how each parameter affects the model's output. The sensitivity analysis identifies key parameters influencing infection rates, such as ingestion rate, disease progression rate, and shedding rate, all of which increase infection. Conversely, higher clearance and recovery rates decrease infection. The study also highlights the potential for cross-species transmission of STH infections between humans and animals, underscoring the One Health concept, which acknowledges the interdependence of human, animal, and environmental health. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2504_03212 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Mathematical Modeling of Soil-Transmitted Helminth Infection: Human-Animal Dynamics with Environmental Reservoirs Imoro, Rafiatu Gavina, Maica Krizna Paller, Vachel Gay Rabajante, Jomar Cortez, Mark Jayson Jose, Editha Populations and Evolution Dynamical Systems Soil-transmitted helminth (STH) infections, one of the most prevalent neglected tropical diseases, pose a significant threat to public health in tropical and subtropical areas. These parasites infect humans and animals through direct contact with contaminated soil or accidental ingestion. This study examines the dynamics of STH transmission using a deterministic compartmental model and nonlinear ordinary differential equations. Our model incorporates the roles humans, animals, and the environment play as reservoirs for spreading STH. We derived the basic reproduction number and demonstrate that the disease-free and endemic equilibrium points are asymptotically stable under specific thresholds. We also performed a sensitivity analysis to determine how each parameter affects the model's output. The sensitivity analysis identifies key parameters influencing infection rates, such as ingestion rate, disease progression rate, and shedding rate, all of which increase infection. Conversely, higher clearance and recovery rates decrease infection. The study also highlights the potential for cross-species transmission of STH infections between humans and animals, underscoring the One Health concept, which acknowledges the interdependence of human, animal, and environmental health. |
| title | Mathematical Modeling of Soil-Transmitted Helminth Infection: Human-Animal Dynamics with Environmental Reservoirs |
| topic | Populations and Evolution Dynamical Systems |
| url | https://arxiv.org/abs/2504.03212 |