Optimization of pulsed saturation transfer MR fingerprinting (ST MRF) acquisition using the Cramér-Rao bound and sequential quadratic programming
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arXiv
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| Autores principales: | , , |
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| Formato: | Preprint |
| Publicado: |
2025
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| _version_ | 1866908603276853248 |
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| author | Vladimirov, Nikita Zaiss, Moritz Perlman, Or |
| author_facet | Vladimirov, Nikita Zaiss, Moritz Perlman, Or |
| contents | Purpose: To develop a method for optimizing pulsed saturation transfer MR fingerprinting (ST MRF) acquisition. Methods: The Cramér-Rao bound (CRB) for variance assessment was employed on Bloch-McConnell-based simulated signals, followed by a numerical sequential quadratic programming optimization and basin-hopping avoidance of local minima. Validation was performed using L-arginine phantoms and healthy human volunteers (n=4) at 3T while restricting the scan time to be less than 40 s. Results: The proposed optimization approach resulted in a significantly improved agreement with reference gold standard values in vivo, compared to baseline non-optimized protocols (8$\%$ lower NRMSE, 7$\%$ higher SSIM, and 15$\%$ higher Pearson's r value, p<0.001). Conclusion: The combination of the CRB with sequential quadratic programming and a rapid Bloch-McConnell simulator offers a means for optimizing and accelerating pulsed CEST and semisolid magnetization transfer (MT) MRF acquisition. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2504_03298 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Optimization of pulsed saturation transfer MR fingerprinting (ST MRF) acquisition using the Cramér-Rao bound and sequential quadratic programming Vladimirov, Nikita Zaiss, Moritz Perlman, Or Medical Physics Purpose: To develop a method for optimizing pulsed saturation transfer MR fingerprinting (ST MRF) acquisition. Methods: The Cramér-Rao bound (CRB) for variance assessment was employed on Bloch-McConnell-based simulated signals, followed by a numerical sequential quadratic programming optimization and basin-hopping avoidance of local minima. Validation was performed using L-arginine phantoms and healthy human volunteers (n=4) at 3T while restricting the scan time to be less than 40 s. Results: The proposed optimization approach resulted in a significantly improved agreement with reference gold standard values in vivo, compared to baseline non-optimized protocols (8$\%$ lower NRMSE, 7$\%$ higher SSIM, and 15$\%$ higher Pearson's r value, p<0.001). Conclusion: The combination of the CRB with sequential quadratic programming and a rapid Bloch-McConnell simulator offers a means for optimizing and accelerating pulsed CEST and semisolid magnetization transfer (MT) MRF acquisition. |
| title | Optimization of pulsed saturation transfer MR fingerprinting (ST MRF) acquisition using the Cramér-Rao bound and sequential quadratic programming |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2504.03298 |