Influence of cellular mechano-calcium feedback in numerical models of cardiac electromechanics
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arXiv
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| Format: | Preprint |
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2025
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| author | Radišić, Irena Regazzoni, Francesco Bucelli, Michele Pagani, Stefano Dede', Luca Quarteroni, Alfio |
| author_facet | Radišić, Irena Regazzoni, Francesco Bucelli, Michele Pagani, Stefano Dede', Luca Quarteroni, Alfio |
| contents | Multiphysics and multiscale mathematical models enable the non-invasive study of cardiac function. These models often rely on simplifying assumptions that neglect certain biophysical processes to balance fidelity and computational cost. In this work, we propose an eikonal-based framework that incorporates mechano-calcium feedback -- the effect of mechanical deformation on calcium-troponin buffering -- while introducing only negligible computational overhead. To assess the impact of mechano-calcium feedback at the organ level, we develop a bidirectionally coupled cellular electromechanical model and integrate it into two cardiac multiscale frameworks: a monodomain-driven model that accounts for geometric feedback on electrophysiology and the proposed eikonal-based approach, which instead neglects geometric feedback. By ensuring consistent cellular model calibration across all scenarios, we isolate the role of mechano-calcium feedback and systematically compare its effects against models without it. Our results indicate that, under baseline conditions, mechano-calcium feedback has minimal influence on overall cardiac function. However, its effects become more pronounced in altered force generation scenarios, such as inotropic modulation. Furthermore, we demonstrate that the eikonal-based framework, despite omitting other types of mechano-electric feedback, effectively captures the role of mechano-calcium feedback at significantly lower computational costs than the monodomain-driven model, reinforcing its utility in computational cardiology. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2504_03447 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Influence of cellular mechano-calcium feedback in numerical models of cardiac electromechanics Radišić, Irena Regazzoni, Francesco Bucelli, Michele Pagani, Stefano Dede', Luca Quarteroni, Alfio Numerical Analysis Multiphysics and multiscale mathematical models enable the non-invasive study of cardiac function. These models often rely on simplifying assumptions that neglect certain biophysical processes to balance fidelity and computational cost. In this work, we propose an eikonal-based framework that incorporates mechano-calcium feedback -- the effect of mechanical deformation on calcium-troponin buffering -- while introducing only negligible computational overhead. To assess the impact of mechano-calcium feedback at the organ level, we develop a bidirectionally coupled cellular electromechanical model and integrate it into two cardiac multiscale frameworks: a monodomain-driven model that accounts for geometric feedback on electrophysiology and the proposed eikonal-based approach, which instead neglects geometric feedback. By ensuring consistent cellular model calibration across all scenarios, we isolate the role of mechano-calcium feedback and systematically compare its effects against models without it. Our results indicate that, under baseline conditions, mechano-calcium feedback has minimal influence on overall cardiac function. However, its effects become more pronounced in altered force generation scenarios, such as inotropic modulation. Furthermore, we demonstrate that the eikonal-based framework, despite omitting other types of mechano-electric feedback, effectively captures the role of mechano-calcium feedback at significantly lower computational costs than the monodomain-driven model, reinforcing its utility in computational cardiology. |
| title | Influence of cellular mechano-calcium feedback in numerical models of cardiac electromechanics |
| topic | Numerical Analysis |
| url | https://arxiv.org/abs/2504.03447 |