Hallucination, reliability, and the role of generative AI in science

Fuente: arXiv
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Autore principale: Rathkopf, Charles
Natura: Preprint
Pubblicazione: 2025
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author Rathkopf, Charles
author_facet Rathkopf, Charles
contents Generative AI increasingly supports scientific inference, from protein structure prediction to weather forecasting. Yet its distinctive failure mode, hallucination, raises epistemic alarm bells. I argue that this failure mode can be addressed by shifting from data-centric to phenomenon-centric assessment. Through case studies of AlphaFold and GenCast, I show how scientific workflows discipline generative models through theory-guided training and confidence-based error screening. These strategies convert hallucination from an unmanageable epistemic threat into bounded risk. When embedded in such workflows, generative models support reliable inference despite opacity, provided they operate in theoretically mature domains.
format Preprint
id arxiv_https___arxiv_org_abs_2504_08526
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Hallucination, reliability, and the role of generative AI in science
Rathkopf, Charles
Computers and Society
Artificial Intelligence
Generative AI increasingly supports scientific inference, from protein structure prediction to weather forecasting. Yet its distinctive failure mode, hallucination, raises epistemic alarm bells. I argue that this failure mode can be addressed by shifting from data-centric to phenomenon-centric assessment. Through case studies of AlphaFold and GenCast, I show how scientific workflows discipline generative models through theory-guided training and confidence-based error screening. These strategies convert hallucination from an unmanageable epistemic threat into bounded risk. When embedded in such workflows, generative models support reliable inference despite opacity, provided they operate in theoretically mature domains.
title Hallucination, reliability, and the role of generative AI in science
topic Computers and Society
Artificial Intelligence
url https://arxiv.org/abs/2504.08526